This was the third Derby d'Italia in a Coppa Italia final, after 1959 and 1965, both won by Juventus. This was the fourth derby of the 2021–22 season, with one league draw and two wins for Internazionale, including the 2021 Supercoppa Italiana.
Road to the final
Note: In all results below, the score of the finalist is given first (H: home; A: away).
^Each team was given only three opportunities to make substitutions, excluding substitutions made at half-time, before the start of extra time and at half-time in extra time.
^"Coppa Italia: Regolamento"(PDF) (in Italian). Lega Nazionale Professionisti Serie A. 8 June 2021. Archived from the original(PDF) on 29 June 2021. Retrieved 27 June 2021.