It will be divided into two phases: the regular season, and the playoff phase.
The league will also be composed of 36 teams divided into two divisions of 18 teams each, whose teams will be divided geographically. Teams will play only other teams in their own division, once at home and once away for a total of 34 matches each.
Teams finishing first in the regular season, plus one team winning the playoff round from each division will be promoted to Serie B; teams finishing last in the regular season, plus two relegation playoff losers from each division will be relegated to Lega Pro Seconda Divisione. In all, four teams will be promoted to Serie B, and six teams will be relegated to Lega Pro Seconda Divisione.
The remaining 26 teams were to come from the teams that played in 2009–10 Lega Pro Prima Divisione that were neither promoted nor relegated. Of those, Arezzo (4th in Girone A), Perugia (11th in Girone A), Rimini (4th in Girone B) and Real Marcianise (12th in Girone B) were also listed by the Covisoc organization as not having met the financial requirements to be admitted. On 17 July 2010 these teams were officially excluded from the league along with Figline (7th in Girone A) by Federal Council's decision.
On 4 August 2010, the eight vacancies created were filled by the following teams, all of which were destined to play in Lega Pro Seconda Divisione for the 2010-11 season before the call-up:
Paganese, which finished 17th in Prima Divisione 2009-10 - Girone A, originally relegated for losing in the playouts.
Pavia, which finished 5th and lost in the playoff semi-finals in Seconda Divisione 2009-10 - Girone A
Bassano Virtus, which finished 7th in Seconda Divisione 2009-10 - Girone B
Nocerina, which finished 13th in Seconda Divisione 2009-10 - Girone B
Barletta, which finished 5th and lost in the playoff semi-finals in Seconda Divisione 2009-10 - Girone C
Siracusa, which finished 6th in Seconda Divisione 2009-10 - Girone C
Gela, which finished 7th in Seconda Divisione 2009-10 - Girone C
Pisa, which finished 1st in Serie D 2009-10 - Girone D
Source: Tutto Lega Pro Rules for classification: 1) points; 2) goal difference; 3) number of goals scored. (C) Champions; (E) Eliminated; (O) Play-off winners; (P) Promoted; (R) Relegated Notes:
Source: Tutto Lega Pro Rules for classification: 1) points; 2) goal difference; 3) number of goals scored. (C) Champions; (O) Play-off winners; (P) Promoted; (R) Relegated Notes:
^Atletico Roma not admitted by the Federal Council and excluded from football.[9]