Penghalang saluran klorida

Penghalang saluran klorida adalah jenis obat yang menghambat transmisi ion (Cl−) melalui saluran klorida.

Asam niflumat adalah salah satu penghalang saluran klorida yang telah digunakan dalam penelitian ilmiah eksperimental.[1] Contoh lainnya adalah asam antrasena-9-karboksilat, penghalang saluran-klorida tipe-CLCN1 kuat yang ditemukan di otot rangka, yang digunakan untuk mempelajari model hewan myotonia congenita.[2]

Beberapa antagonis reseptor glisina dan reseptor GABAA juga bertindak sebagai penghalang saluran klorida.

Lihat pula

Referensi

  1. ^ Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658 alt=Dapat diakses gratis. PMID 6736917. 
  2. ^ Villegas-Navarro A, Martinez-Morales M, Morales-Aguilera A (Maret 1986). "Pharmacokinetics of anthracene-9-carboxylic acid, a potent myotonia-inducer". Archives Internationales de Pharmacodynamie et de Thérapie. 280 (1): 5–21. PMID 3718080. 

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