蜕皮激素受体(英語:ecdysone receptor,缩写EcR,或称为蜕皮酮受体)是节肢动物的一种核受体,代号NR1H1,调控其生长发育以及繁殖。受体与蜕皮激素结合后激活,与超气门蛋白(ultraspiracle protein,USP,核受体代号NR2B4)形成非共价异二聚体进入细胞核。在各种节肢动物中,昆虫的蜕皮激素受体研究地最为深入,并根据其结构开发了专门的选择性杀虫剂。
参考文献
- ^ PDB 1R1K; Billas IM, Iwema T, Garnier JM, Mitschler A, Rochel N, Moras D. Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor. Nature. November 2003, 426 (6962): 91–6. PMID 14595375. doi:10.1038/nature02112.
- ^ Clayton GM, Peak-Chew SY, Evans RM, Schwabe JW. The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation. Proceedings of the National Academy of Sciences of the United States of America. February 2001, 98 (4): 1549–54. PMC 29294 . PMID 11171988. doi:10.1073/pnas.041611298.