Olfaktör reseptör

Olfaktör reseptörler olfaktor reseptör nöronlarının hücre zarında bulunan ve koku moleküllerinin tespitinden sorumlu reseptörlerdir. Aktive olmuş koku reseptörleri sinir uyarılarının beyne iletilmesindeki sinyal iletimi kaskadını başlatılar. Bu reseptörler G protein-kenetli reseptörler (GPCRs) ailesinin bir üyesi olan rodopsin-benzeri reseptörler grubunda yer alırlar.[1][2] Koku reseptörleri insanlarda 900'den fazla gen içeren bir multigen ailesi tarafından kodlanırlar.[3]

Kaynakça

  1. ^ Gaillard I, Rouquier S, Giorgi D (2004). "Olfactory receptors". Cell. Mol. Life Sci. 61 (4). ss. 456-69. doi:10.1007/s00018-003-3273-7. PMID 14999405. 
  2. ^ Hussain A, Saraiva LR, Korsching SI (2009). "Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts". PNAS. 106 (11). ss. 4313-8. Bibcode:2009PNAS..106.4313H. doi:10.1073/pnas.0803229106. PMC 2657432 $2. PMID 19237578. 
  3. ^ Niimura Y and Nei M (2003). "Evolution of olfactory receptor genes in the human genome". PNAS. 100 (21). ss. 12235-40. Bibcode:2003PNAS..10012235N. doi:10.1073/pnas.1635157100. PMC 218742 $2. PMID 14507991. 

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