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Tropinon reduktaza I
Tropinon reduktaza I
Identifikatori
EC broj	1.1.1.293
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

Tropinon reduktaza I (EC 1.1.1.293, tropinonska reduktaza, TR-I) je enzim sa sistematskim imenom tropin:NADP⁺ oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

tropin + NADP⁺

\rightleftharpoons

tropinon + NADPH + H⁺

Ovaj enzim zajedno sa EC 1.1.1.236, tropinonskom reduktazom II, predstavlja tačku grananja u metabolizmu tropanskih alkaloida. Tropin (produkt enzima EC 1.1.1.293) se inkorporiraj u hiosciamin i skopolamin, dok je pseudotropin (produkt enzima EC 1.1.1.236) prvi specifični metabolit na putu do kalistegina. Oba enzima su uvek zajedno prisutna kod vrsta koje formiraju tropanske alkaloide. Oni imaju zajednički supstrat, tropinon, i strogo su stereospecifični.

Reference

^ Couladis, M.M, Friesen, J.B., Landgrebe, M.E. and Leete, E. (1991). „Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots of Datura innoxia”. Pytochemistry. 30: 801—805.
^ Nakajima, K., Hashimoto, T. and Yamada, Y. (1993). „Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor”. Proc. Natl. Acad. Sci. USA. 90: 9591—9595. PMID 8415746.
^ Dräger, B. (2006). „Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism”. Phytochemistry. 67: 327—337. PMID 16426652.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Tropinone+reductase+I на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Couladis, M.M, Friesen, J.B., Landgrebe, M.E. and Leete, E. (1991). „Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots of Datura innoxia”. Pytochemistry. 30: 801—805.

[2] Nakajima, K., Hashimoto, T. and Yamada, Y. (1993). „Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor”. Proc. Natl. Acad. Sci. USA. 90: 9591—9595. PMID 8415746.

[3] Dräger, B. (2006). „Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism”. Phytochemistry. 67: 327—337. PMID 16426652.

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