TRNK (guanin6-N2)-metiltransferaza

TRNK (guanin^6-N^2)-metiltransferaza
Identifikatori
EC broj	2.1.1.256
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

TRNK (guanin⁶-N²)-metiltransferaza (EC 2.1.1.256, metiltransferaza Trm14, m2G6 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanin6-N2)-metiltransferaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + guanin⁶ u tRNK ${\displaystyle \rightleftharpoons }$ S-adenozil-L-homocistein + N²-metilguanin⁶ u tRNK

Ovaj enzim specifično metiliše guanin⁶ u N² poziciji unutar tRNK.

Reference

1. Menezes, S., Gaston, K.W., Krivos, K.L., Apolinario, E.E., Reich, N.O., Sowers, K.R., Limbach, P.A. and Perona, J.J. (2011). „Formation of m²G⁶ in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14”. Nucleic Acids Res. 39: 7641—7655. PMID 21693558. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

• TRNA+(guanine6-N2)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)