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PMC	članci
PubMed	članci
NCBI	proteini

Serinska proteaza-2
Serinska proteaza-2
Identifikatori
EC broj	3.4.21.104
CAS broj	214915-16-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Serinska proteaza-2 (EC 3.4.21.104, MASP-2, MASP2, MBP-asocirana serinska proteaza-2, manozno-vezujuća proteaza-2 asocirana sa lektinom, p100, manan-vezujuća lektin-asocirana serin peptidaza 2) je enzim.^[1]^[2]^[3]^[4]^[5]^[6]^[7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Selektivno razlaganje iza Arg²²³ u komplementnoj komponenti C2 (-Ser-Leu-Gly-Arg-Lys-Ile-GlnIle) i iza Arg⁷⁶ u komplementnoj komponenti C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)

Ovaj manan-vezujući lektin (MBL) prepoznaje obrsce neutralnih ugljenih hidrata.

Reference

^ Matsushita, M. & Fujita, T. (1992). „Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease”. J. Exp. Med. 176: 1497—1502. PMID 1460414.
^ Thiel, S., Vorup-Jensen, T., Stover, C.M., Schwaeble, W., Laursen, S.B., Poulsen, K., Willis, A.C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K.B. and Jensenius, J.C. (1997). „A second serine protease associated with mannan-binding lectin that activates complement”. Nature. 386: 506—510. PMID 9087411.
^ Rossi, V., Cseh, S., Bally, I., Thielens, N.M., Jensenius, J.C. and Arlaud, G.J. (2001). „Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2”. J. Biol. Chem. 276: 40880—40887. PMID 11527969.
^ Ambrus, G., Gal, P., Kojima, M., Szilagyi, K., Balczer, J., Antal, J., Graf, L., Laich, A., Moffatt, B.E., Schwaeble, W., Sim, R.B. and Zavodszky, P. (2003). „Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments”. J. Immunol. 170: 1374—1382. PMID 12538697.
^ Harmat, V., Gal, P., Kardos, J., Szilagyi, K., Ambrus, G., Vegh, B., Naray-Szabo, G. and Zavodszky, P. (2004). „The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions”. J. Mol. Biol. 342: 1533—1546. PMID 15364579.
^ Chen, C.B. & Wallis, R. (2004). „Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases”. J. Biol. Chem. 279: 26058—26065. PMID 15060079.
^ Teillet, F., Dublet, B., Andrieu, J.P., Gaboriaud, C., Arlaud, G.J. and Thielens, N.M. (2005). „The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases”. J. Immunol. 174: 2870—2877. PMID 15728497.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Mannan-binding+lectin-associated+serine+protease-2 на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Matsushita, M. & Fujita, T. (1992). „Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease”. J. Exp. Med. 176: 1497—1502. PMID 1460414.

[2] Thiel, S., Vorup-Jensen, T., Stover, C.M., Schwaeble, W., Laursen, S.B., Poulsen, K., Willis, A.C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K.B. and Jensenius, J.C. (1997). „A second serine protease associated with mannan-binding lectin that activates complement”. Nature. 386: 506—510. PMID 9087411.

[3] Rossi, V., Cseh, S., Bally, I., Thielens, N.M., Jensenius, J.C. and Arlaud, G.J. (2001). „Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2”. J. Biol. Chem. 276: 40880—40887. PMID 11527969.

[4] Ambrus, G., Gal, P., Kojima, M., Szilagyi, K., Balczer, J., Antal, J., Graf, L., Laich, A., Moffatt, B.E., Schwaeble, W., Sim, R.B. and Zavodszky, P. (2003). „Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments”. J. Immunol. 170: 1374—1382. PMID 12538697.

[5] Harmat, V., Gal, P., Kardos, J., Szilagyi, K., Ambrus, G., Vegh, B., Naray-Szabo, G. and Zavodszky, P. (2004). „The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions”. J. Mol. Biol. 342: 1533—1546. PMID 15364579.

[6] Chen, C.B. & Wallis, R. (2004). „Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases”. J. Biol. Chem. 279: 26058—26065. PMID 15060079.

[7] Teillet, F., Dublet, B., Andrieu, J.P., Gaboriaud, C., Arlaud, G.J. and Thielens, N.M. (2005). „The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases”. J. Immunol. 174: 2870—2877. PMID 15728497.

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