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Sekoizolaricirezinol dehidrogenaza
Sekoizolaricirezinol dehidrogenaza
Identifikatori
EC broj	1.1.1.331
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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Sekoizolaricirezinol dehidrogenaza (EC 1.1.1.331, sekoizolaricirezinolna dehidrogenaza) je enzim sa sistematskim imenom (-)-sekoizolaricirezinol:NAD⁺ oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(-)-sekoizolaricirezinol + 2 NAD⁺

\rightleftharpoons

(-)-matairezinol + 2 NADH + 2 H⁺

Ovaj enzim je izolovan iz biljki Forsythia intermedia i Podophyllum peltatum. In vitro se formira intermedijerni laktol.

Reference

^ Xia, Z.Q., Costa, M.A., Pelissier, H.C., Davin, L.B. and Lewis, N.G. (2001). „Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection”. J. Biol. Chem. 276: 12614—12623. PMID 11278426.
^ Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G. and Kang, C. (2005). „Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans”. J. Biol. Chem. 280: 12917—12926. PMID 15653677.
^ Moinuddin, S.G., Youn, B., Bedgar, D.L., Costa, M.A., Helms, G.L., Kang, C., Davin, L.B. and Lewis, N.G. (2006). „Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum”. Org. Biomol. Chem. 4: 808—816. PMID 16493463.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Secoisolariciresinol+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Xia, Z.Q., Costa, M.A., Pelissier, H.C., Davin, L.B. and Lewis, N.G. (2001). „Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection”. J. Biol. Chem. 276: 12614—12623. PMID 11278426.

[2] Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G. and Kang, C. (2005). „Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans”. J. Biol. Chem. 280: 12917—12926. PMID 15653677.

[3] Moinuddin, S.G., Youn, B., Bedgar, D.L., Costa, M.A., Helms, G.L., Kang, C., Davin, L.B. and Lewis, N.G. (2006). „Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum”. Org. Biomol. Chem. 4: 808—816. PMID 16493463.

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