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Polinukleotid 5'-hidroksil-kinaza
Polinukleotid 5'-hidroksil-kinaza
Identifikatori
EC broj	2.7.1.78
CAS broj	37211-65-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
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NCBI	proteini

Polinukleotid 5'-hidroksil-kinaza (EC 2.7.1.78, ATP:5'-defosfopolinukleotid 5'-fosfataza, PNK, polinukleotid 5'-hidroksil kinaza (fosforilacija), 5'-hidroksil polinukleotid kinaza, 5'-hidroksil poliribonukleotid kinaza, 5'-hidroksil RNK kinaza, DNK 5'-hidroksil kinaza, DNK kinaza, polinukleotidna kinaza, polinukleotid 5'-hidroksi-kinaza) je enzim sa sistematskim imenom ATP:5'-defosfopolinukleotid 5'-fosfotransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + 5'-defosfo-DNK

\rightleftharpoons

ADP + 5'-fosfo-DNK

Ovaj enzim takođe deluje na 5'-defosfo-RNK 3'-mononukleotide.

Reference

^ Novogrodsky, A. & Hurwitz, J. (1966). „The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5′-hydroxyl termini”. J. Biol. Chem. 241: 2923—2932. PMID 4287929.
^ Novogrodsky, A., Tal, M., Traub, A. and Hurwitz, J. (1966). „The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5′-hydroxyl polynucleotide kinase”. J. Biol. Chem. 241: 2933—2943. PMID 4287930.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Polynucleotide+5'-hydroxyl-kinase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Novogrodsky, A. & Hurwitz, J. (1966). „The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5′-hydroxyl termini”. J. Biol. Chem. 241: 2923—2932. PMID 4287929.

[2] Novogrodsky, A., Tal, M., Traub, A. and Hurwitz, J. (1966). „The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5′-hydroxyl polynucleotide kinase”. J. Biol. Chem. 241: 2933—2943. PMID 4287930.

[1]

[2]