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Piroglutamilna peptidaza I
Piroglutamilna peptidaza I
Identifikatori
EC broj	3.4.19.3
CAS broj	9075-21-2
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Piroglutamilna peptidaza I (EC 3.4.19.3, 5-oksoprolilna peptidaza, piraza, piroglutamatna aminopeptidaza, piroglutamilna aminopeptidaza, L-piroglutamil peptidna hidrolaza, pirolidon-karboksilna peptidaza, pirolidon-karboksilatna peptidaza, pirolidonilna peptidaza, L-pirolidonkarboksilatna peptidaza, piroglutamidaza, pirolidonkarboksilol peptidaza) je enzim.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje N-terminalne piroglutamilne grupe sa polipeptida, pri čemu druga aminokiselina generalno nije Pro

Ovaj cisteinska peptidaza, je izolovana iz bakterija, biljki i životinja.

Reference

^ Tsuru, D., Nakamura, K., Yoshimoto, T. and Fujiwara, K. (1984). „Pyroglutamyl-peptidase from Bacillus amyloliquefaciens. An improved purification method and some properties of the enzyme”. Biochim. Biophys. Acta. 791: 117—122.
^ Awadé, A.C., Cleuziat, P., Gonzalès, T. and Robert-Baudouy, J. (1994). „Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins”. Proteins: Struct. Funct. Genet. 20: 34—51. PMID 7824521.
^ Patti, J.M., Schneider, A., Garza, N. and Boles, J.O. (1995). „Isolation and characterization of pcp, a gene encoding a pyrrolidone carboxyl peptidase in Staphylococcus aureus'”. Gene. 166: 95—99. PMID 8529900.
^ Le Saux, O., Gonzalès, T. and Robert-Baudouy, J. (1996). „Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase”. J. Bacteriol. 178: 3308—3313. PMID 8655512.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Pyroglutamyl-peptidase+I на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Tsuru, D., Nakamura, K., Yoshimoto, T. and Fujiwara, K. (1984). „Pyroglutamyl-peptidase from Bacillus amyloliquefaciens. An improved purification method and some properties of the enzyme”. Biochim. Biophys. Acta. 791: 117—122.

[2] Awadé, A.C., Cleuziat, P., Gonzalès, T. and Robert-Baudouy, J. (1994). „Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins”. Proteins: Struct. Funct. Genet. 20: 34—51. PMID 7824521.

[3] Patti, J.M., Schneider, A., Garza, N. and Boles, J.O. (1995). „Isolation and characterization of pcp, a gene encoding a pyrrolidone carboxyl peptidase in Staphylococcus aureus'”. Gene. 166: 95—99. PMID 8529900.

[4] Le Saux, O., Gonzalès, T. and Robert-Baudouy, J. (1996). „Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase”. J. Bacteriol. 178: 3308—3313. PMID 8655512.

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