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Piridoksin 5'-fosfat sintaza
Piridoksin 5'-fosfat sintaza
Identifikatori
EC broj	2.6.99.2
CAS broj	230310-47-1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Piridoksin 5'-fosfat sintaza (EC 2.6.99.2, piridoksin 5-fosfat fosfo lijaza, PNP sintaza, PdxJ) je enzim sa sistematskim imenom 1-dezoksi-D-ksiluloza-5-fosfat:3-amino-2-oksopropil fosfat 3-amino-2-oksopropiltransferaza (fosfat-hidroliza; ciklizacija).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-dezoksi-D-ksiluloza 5-fosfat + 3-amino-2-oksopropil fosfat

\rightleftharpoons

piridoksin 5'-fosfat + fosfat + 2H₂O

Kod Escherichia coli, koenzim piridoksal 5'-fosfat se sintetizuje de novo.

Reference

^ Garrido-Franco, M. (2003). „Pyridoxine 5′-phosphate synthase: de novo synthesis of vitamin B₆ and beyond”. Biochim. Biophys. Acta. 1647: 92—97. PMID 12686115.
^ Garrido-Franco, M., Laber, B., Huber, R. and Clausen, T. (2002). „Enzyme-ligand complexes of pyridoxine 5′-phosphate synthase: implications for substrate binding and catalysis”. J. Mol. Biol. 321: 601—612. PMID 12206776.
^ Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S. (1999). „Vitamin B₆ biosynthesis: formation of pyridoxine 5′-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein”. FEBS Lett. 449: 45—48. PMID 10225425.
^ Franco, M.G., Laber, B., Huber, R. and Clausen, T. (2001). „Structural basis for the function of pyridoxine 5′-phosphate synthase”. Structure. 9: 245—253. PMID 11286891.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Pyridoxine+5'-phosphate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Garrido-Franco, M. (2003). „Pyridoxine 5′-phosphate synthase: de novo synthesis of vitamin B₆ and beyond”. Biochim. Biophys. Acta. 1647: 92—97. PMID 12686115.

[2] Garrido-Franco, M., Laber, B., Huber, R. and Clausen, T. (2002). „Enzyme-ligand complexes of pyridoxine 5′-phosphate synthase: implications for substrate binding and catalysis”. J. Mol. Biol. 321: 601—612. PMID 12206776.

[3] Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S. (1999). „Vitamin B₆ biosynthesis: formation of pyridoxine 5′-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein”. FEBS Lett. 449: 45—48. PMID 10225425.

[4] Franco, M.G., Laber, B., Huber, R. and Clausen, T. (2001). „Structural basis for the function of pyridoxine 5′-phosphate synthase”. Structure. 9: 245—253. PMID 11286891.

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