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N-acetiltransferaza 2 (arilamin N-acetiltransferaza)
N-acetiltransferaza 2 (arilamin N-acetiltransferaza)
	PDB prikaz baziran na 2pfr.
Dostupne strukture
	2PFR
Identifikatori
Simboli	NAT2; AAC2; NAT-2; PNAT
Vanjski ID	OMIM: 612182 MGI: 97279 HomoloGene: 115468 GeneCards: NAT2 Gene
EC broj	2.3.1.5
Ontologija gena
Molekularna funkcija	• aktivnost arilamin N-acetiltransferaze;
Celularna komponenta	• citosol;
Biološki proces	• proces ksenobiotičkog metabolizma; • metabolički proces malih molekula;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	10
Ensembl	ENSG00000156006
UniProt	P11245
RefSeq (mRNA)	NM_000015
RefSeq (protein)	NP_000006
Lokacija (UCSC)	Chr 8:; 18.25 - 18.26 Mb
PubMed pretraga	[1]

N-acetiltransferaza 2 (arilamin N-acetiltransferaza), takođe poznata kao NAT2, je enzim koji je kod čoveka kodiran NAT2 genom.^[1]

Funkcija

Ovaj gen kodira jedan tip N-acetiltransferaza. NAT2 izozim funkcioniše tako što aktivira i deaktivira arilaminske i hidrazinske lekove i karcinogene. Polimorfizam ovog gena je odgovoran za N-acetilacioni polimorfizam kojim se ljudska populacija segregira u brze, srednje i spore acetilatorne fenotipe. Polimorfizmi NAT2 su takođe povezani za povećanom učestalošću kancera i toksičnošću lekova. Drugi arilaminski N-acetiltransferazni gen (NAT1) je lociran blizo NAT2.^[2]

Predviđanje fenotipa

NAT2 acetilatorni fenotip se može predvideti iz NAT2 genotipa (SNP kombinacije koje data osoba poseduje).^[3]^[4]

Reference

^ Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV (1995). „Nomenclature for N-acetyltransferases”. Pharmacogenetics. 5 (1): 1—17. PMID 7773298. doi:10.1097/00008571-199502000-00001.
^ „Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)”.
^ „NAT2PRED: a computational predictor of the human N-AcetylTransferase-2 (NAT2) acetylator phenotype”. State University of New York – Albany. Архивирано из оригинала 22. 05. 2009. г. Приступљено 30. 4. 2009.
^ Kuznetsov IB, McDuffie M, Moslehi R (2009). „A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype”. Bioinformatics (Oxford, England). 25 (9): 1185—6. PMC 2672629 . PMID 19261719. doi:10.1093/bioinformatics/btp121.

Literatura

Vatsis KP; Weber WW; Bell DA; et al. (1995). „Nomenclature for N-acetyltransferases.”. Pharmacogenetics. 5 (1): 1—17. PMID 7773298. doi:10.1097/00008571-199502000-00001.
Windmill KF; McKinnon RA; Zhu X; et al. (1997). „The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.”. Mutat. Res. 376 (1-2): 153—60. PMID 9202751. doi:10.1016/S0027-5107(97)00038-9.
Lan Q; Rothman N; Chow WH; et al. (2003). „No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.”. Cancer Epidemiol. Biomarkers Prev. 12 (4): 384—6. PMID 12692115.
Ochs-Balcom HM, Wiesner G, Elston RC (2007). „A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.”. Am. J. Epidemiol. 166 (3): 246—54. PMID 17535831. doi:10.1093/aje/kwm066.
Sanderson S, Salanti G, Higgins J (2007). „Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.”. Am. J. Epidemiol. 166 (7): 741—51. PMID 17675654. doi:10.1093/aje/kwm167.
Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

NAT2 human gene location in the UCSC Genome Browser.
NAT2 human gene details in the UCSC Genome Browser.

[pmid7773298-1] Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV (1995). „Nomenclature for N-acetyltransferases”. Pharmacogenetics. 5 (1): 1—17. PMID 7773298. doi:10.1097/00008571-199502000-00001.

[2] „Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)”.

[urlNAT2PRED:_a_computational_predictor_of_the_human_N-AcetylTransferase-2_(NAT2)_acetylator_phenotype-3] „NAT2PRED: a computational predictor of the human N-AcetylTransferase-2 (NAT2) acetylator phenotype”. State University of New York – Albany. Архивирано из оригинала 22. 05. 2009. г. Приступљено 30. 4. 2009.

[pmid19261719-4] Kuznetsov IB, McDuffie M, Moslehi R (2009). „A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype”. Bioinformatics (Oxford, England). 25 (9): 1185—6. PMC 2672629 . PMID 19261719. doi:10.1093/bioinformatics/btp121.

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