Metilarsonat reduktaza

Metilarsonat reduktaza
Identifikatori
EC broj	1.20.4.2
CAS broj	254889-62-8
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Metilarsonat reduktaza (EC 1.20.4.2, MMA(V) reduktaza) je enzim sa sistematskim imenom glutation:metilarsonat oksidoreduktaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

metilarsonat + 2 glutation ${\displaystyle \rightleftharpoons }$ metilarsonit + glutation disulfid + H₂O

Produkt, Me-As(OH)² (metilarsenitna kiselina), se biološki metiluje posredstvom enzima EC 2.1.1.137, arsenit metiltransferaze, čime se formira kakodilinska kiselinu.

Reference

1. Zakharyan, R.A. & Aposhian, H.V. (1999). „Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase”. Chem. Res. Toxicol. 12: 1278—1283. PMID 10604879. 

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

• Methylarsonate+reductase на US National Library of Medicine Medical Subject Headings (MeSH)