Metilamin-korinoid protein Co-metiltransferaza

Metilamin-korinoid protein Co-metiltransferaza
Identifikatori
EC broj	2.1.1.248
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Metilamin-korinoid protein Co-metiltransferaza (EC 2.1.1.248, mtmB (gen), monometilaminska metiltransferaza) je enzim sa sistematskim imenom monometilamin:5-hidroksibenzimidazolilkobamid Co-metiltransferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

metilamin + [Co(I) metilamin-specifični korinoidni protein] ${\displaystyle \rightleftharpoons }$ [metil-Co(III) metilamin-specifični korinoidni protein] + amonijak

Enzim koji katalizuje transfer metil grupa sa metilamina na metilamin-specifični korinoidni protein (MtmC), učestvuje u metanogenezi. Ovaj enzim sadrži neobičnu aminokiselinu pirolizin.

Reference

1. Burke, S.A. & Krzycki, J.A. (1997). „Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri”. J. Biol. Chem. 272: 16570—16577. PMID 9195968. 
2. Burke, S.A., Lo, S.L. and Krzycki, J.A. (1998). „Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine”. J. Bacteriol. 180: 3432—3440. PMID 9642198. CS1 одржавање: Вишеструка имена: списак аутора (веза)
3. Krzycki, J.A. (2004). „Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases”. Curr. Opin. Chem. Biol. 8: 484—491. PMID 15450490. 

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

• Methylamine---corrinoid+protein+Co-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)