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Meprin-A (EC 3.4.24.18, endopeptidaza-2, meprin, hidrolaza N-benzoil-L-tirozil-p-aminobenzojeve kiseline, PABA-peptidna hidrolaza, PPH) je enzim.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteinskih i peptidnih supstrata preferentno na karboksilnoj strani hidrofobnih ostataka

Ova membranska metaloendopeptidaza je prisutna u bubrezima pacova i miševa.

Reference

^ Beynon, R.J., Shannon, J.D. and Bond, J.S. (1981). „Purification and characterization of a metallo-endoproteinase from mouse kidney”. Biochem. J. 199: 591—598. PMID 7041888.
^ Butler, P.E., McKay, M.J. and Bond, J.S. (1987). „Characterization of meprin, a membrane-bound metalloendopeptidase from mouse kidney”. Biochem. J. 241: 229—235. PMID 3105525.
^ Stephenson, S.L. & Kenny, A.J. (1988). „The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme 'endopeptidase-2′ and by rat microvillar membranes”. Biochem. J. 255: 45—51. PMID 2461706.
^ Sterchi, E.E., Naim, H.Y., Lentze, M.J., Hauri, H.-P. Fransen, J.A.M. (1988). „N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: a metalloendopeptidase of the human intestinal microvillus membrane which degrades biologically active peptides”. Arch. Biochem. Biophys. 265: 105—118. PMID 3261961.
^ Barnes, K., Ingram, J. and Kenny, A.J. (1989). „Proteins of the kidney microvillar membrane. Structural and immunochemical properties of rat endopeptidase-2 and its immunohistochemical localization in tissues of rat and mouse”. Biochem. J. 264: 335—346. PMID 2690825.