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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Kaspaza-9
Kaspaza-9
Identifikatori
EC broj	3.4.22.62
CAS broj	180189-96-2
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Kaspaza-9 (EC 3.4.22.62, CASP-9, ICE-slična apoptotička proteaza 6, ICE-LAP6, apoptotička proteaza Mch-6, apoptotičko proteazni aktivirajući faktor 3, APAF-3) je enzim.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji i preferentno je His u poziciji P2. Preferentno dolazi do razlaganja sekvence Leu-Gly-His-Asp-Xaa

Kaspaza-9 je efektor/izvršilac kaspaze, kao što su i kaspaza-2 (EC 3.4.22.55), kaspaza-8 (EC 3.4.22.61) i kaspaza-10 (EC 3.4.22.63).

Reference

^ Chang, H.Y. & Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821—846. PMID 11104820.
^ Yin, Q., Park, H.H., Chung, J.Y., Lin, S.C., Lo, Y.C., da Graca, L.S., Jiang, X. and Wu, H. (2006). „Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine”. Mol. Cell. 22: 259—268. PMID 16630893.
^ Boatright, K.M., Renatus, M., Scott, F.L., Sperandio, S., Shin, H., Pedersen, I.M., Ricci, J.E., Edris, W.A., Sutherlin, D.P., Green, D.R. and Salvesen, G.S. (2003). „A unified model for apical caspase activation”. Mol. Cell. 11: 529—541. PMID 12620239.
^ Salvesen, G.S. & Boatright, K.M. (2004). „Caspase-9”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes (2nd изд.). London: Elsevier. стр. 1296—1298.

Литература

Salvesen, G.S. & Boatright, K.M. (2004). „Caspase-9”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes (2nd изд.). London: Elsevier. стр. 1296—1298.

Spoljašnje veze

Caspase-9 на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Chang, H.Y. & Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821—846. PMID 11104820.

[2] Yin, Q., Park, H.H., Chung, J.Y., Lin, S.C., Lo, Y.C., da Graca, L.S., Jiang, X. and Wu, H. (2006). „Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine”. Mol. Cell. 22: 259—268. PMID 16630893.

[3] Boatright, K.M., Renatus, M., Scott, F.L., Sperandio, S., Shin, H., Pedersen, I.M., Ricci, J.E., Edris, W.A., Sutherlin, D.P., Green, D.R. and Salvesen, G.S. (2003). „A unified model for apical caspase activation”. Mol. Cell. 11: 529—541. PMID 12620239.

[4] Salvesen, G.S. & Boatright, K.M. (2004). „Caspase-9”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes (2nd изд.). London: Elsevier. стр. 1296—1298.

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