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Jararhagin (EC 3.4.24.73, HF2-proteinaza, JF1) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza -His¹⁰-Leu-, -Ala¹⁴-Leu-, -Tyr¹⁶-Leu- i -Phe²⁴-Phe- veza u insulinskom B lancu

Ova hemoragička endopeptidaza je prisutna u venumu zmije Bothrops jararaca.

Reference

^ Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). „Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca”. Ур.: Ohsaka, A., Hayashi, K. and Sawai, Y. Animal, Plant and Microbial Toxins. New York: Plenum Press. стр. 111—121.
^ Assakura, M.T., Reichl, A.P. and Mandelbaum, F.R. (1986). „Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)”. Toxicon. 24: 943—946. PMID 3810664.
^ Paine, M.J.I., Desmond, H.P., Theakston, R.D.G. and Crampton, J.M. (1992). „Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family”. J. Biol. Chem. 267: 22869—22876. PMID 1385408.

Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). „Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca”. Ур.: Ohsaka, A., Hayashi, K. and Sawai, Y. Animal, Plant and Microbial Toxins. New York: Plenum Press. стр. 111—121.