Irazepin![]() |
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7-hloro-5-(2-fluorofenil)-1-(2-izotiocianatoetil)-3H-1,4-benzodiazepin-2-on |
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| CAS broj | 71735-92-7  Y |
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| PubChem | CID 194406 |
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| ChemSpider | 168688 Y |
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| Formula | C18H13ClFN3OS |
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| Molarna masa | 373.83 g/mol |
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C1C(=O)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CCN=C=S
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InChI=1S/C18H13ClFN3OS/c19-12-5-6-16-14(9-12)18(13-3-1-2-4-15(13)20)22-10-17(24)23(16)8-7-21-11-25/h1-6,9H,7-8,10H2 Key:LTKSVYFAUMFQML-UHFFFAOYSA-N
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Irazepin (Ro 7-1986/1) je benzodiazepinski derivat koji sadrži izotiocijanatnu funkcionalnu grupu.[1] On je nekompetitivni antagonist benzodiazepinskog mesta vezivanja.[2] Irazepin i drugi alkilirajući benzodiazepin, kenazepin, se vezuju za moždane benzodiazepinske receptore u nekompetitivnom (kovalentnom) maniru in vitro, i mogu da imaju dugotrajni antikonvulsivni efekat.[3]
Reference
- ^ Edited by Ganellin, CR; Triggle, DJ (1999). Dictionary of Pharmacological Agents. (1st изд.). London: Chapman & Hall. ISBN 9780412466304.
- ^ Hall, Ian K.M. Morton, Judith M. (1999). Concise Dictionary of Pharmacological Agents Properties and Synonyms. Dordrecht: Springer Netherlands. стр. 156. ISBN 978-94-011-4439-1.
- ^ Williams, EF; Rice, KC; Mattson, M; Paul, SM; Skolnick, P (1981). „In Vivo Effects of Two Novel Alkylating Benzodiazepines, Irazepine and Kenazepine”. Pharmacology, Biochemistry, and Behavior. 14 (4): 487—91. PMID 7232472. doi:10.1016/0091-3057(81)90307-5.
