Heparozan-N-sulfat-glukuronatna 5-epimeraza

Heparozan-N-sulfat-glukuronatna 5-epimeraza
Identifikatori
EC broj5.1.3.17
CAS broj112567-86-9
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Heparozan-N-sulfat-glukuronatna 5-epimeraza (EC 5.1.3.17, heparozanska epimeraza, heparosan-N-sulfat-D-glukuronazil 5-epimeraza, C-5 uronozilna epimeraza, poliglukuronatna epimeraza, D-glukuronilna C-5 epimeraza, poli((1,4)-beta-D-glukuronazil-(1,4)-N-sulfo-alfa-D-glukozaminil) glukurona-5-epimeraza) je enzim sa sistematskim imenom poli((1->4)-beta-D-glukuronasil-(1->4)-N-sulfo-alfa-D-glukozaminil) glukurona-5-epimeraza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

heparozan-N-sulfat D-glukuronat heparozan-N-sulfat L-iduronat

Ovaj enzim deluje na D-glukuronazilne ostatke susedne sa sulfatisanim D-glukozaminskim jedinicama u heparinskom prekurzoru.

Reference

  1. ^ Jacobsson, I., Bäckström, G., Höök, M., Lindahl, U., Feingold, D.S., Malmström, A. and Rodén, L. (1979). „Biosynthesis of heparin. Assay and properties of the microsomal uronosyl C-5 epimerase”. J. Biol. Chem. 254: 2975—2982. PMID 107165. 

Literatura

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