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Protein toplotnog šoka 70 kDa 1A
Protein toplotnog šoka 70 kDa 1A
	PDB prikaz baziran na 1hjo.
Dostupne strukture
	1hjo, 1s3x, 1xqs
Identifikatori
Simboli	HSPA1A; HSP70-1; HSP72; HSPA1; HSPA1B; HSPA1A; HSP70-2
Vanjski ID	OMIM: 140550 MGI: 99517 HomoloGene: 74294 GeneCards: HSPA1A Gene
Ontologija gena
Molekularna funkcija	• vezivanje nukleotida; • ATP vezivanje; • vezivanje nesavijenog proteina;
Celularna komponenta	• jedro; • citoplazma; • mitohondrija; • endoplazmatični retikulum;
Biološki proces	• proteinsko savijanje; • respons na nesavijeni protein; • iRNK katabolički proces; • anti-apoptoza;
Ortolozi
Vrsta	Čovek
Entrez	3303
Ensembl	ENSG00000204389
UniProt	P08107
RefSeq (mRNA)	NM_005345
RefSeq (protein)	NP_005336
Lokacija (UCSC)	Chr 6:; 31.78 - 31.79 Mb
PubMed pretraga	[1]

HSPA1A, protein toplotnog šoka 70 kDa 1, je protein koji je kod čoveka kodiran HSPA1A genom.

Ovaj gen ne sadrži introne. On je član familije proteina toplotnog šoka 70. Zajedno s drugim proteinima toplotnog šoka, ovaj protein sprečava agregaciju postojećih proteina i posreduje savijanje novo transliranih proteina u citosolu i organelama. On takođe učestvuje u ubikvitin-proteasom putu tako što ostvaruje interakcije sa AU-bogatim elementom RNK-vezujućeg proteina 1. Ovaj gen je lociran u regionu klase III glavnog histokompatibilnostnog kompleksa, u klasteru sa dva blisko srodna gena koji kodiraju slične proteine.^[1]

Interakcije

Za HSPA1A je bilo pokazano da interaguje sa ASK1,^[2] STUB1,^[3]^[4] MSR1,^[5] BAG3,^[6]^[7] Parkinovom ligazom,^[4] Fankonijeva anemija, komplementaciona grupa C,^[8]^[9] GPR37,^[4] HSF1^[10]^[11] i AIFM1.^[12]^[13]

Reference

^ „Entrez Gene: HSPA1A heat shock 70kDa protein 1A”.
^ Park, Hee-Sae; Cho Ssang-Goo; et al. (2002). „Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1”. Mol. Cell. Biol. United States. 22 (22): 7721—30. ISSN 0270-7306. PMC 134722 . PMID 12391142. doi:10.1128/MCB.22.22.7721-7730.2002.
^ Ballinger, C A; Connell P; et al. (1999). „Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions”. Mol. Cell. Biol. UNITED STATES. 19 (6): 4535—45. ISSN 0270-7306. PMC 104411 . PMID 10330192.
^ ^а ^б ^в Imai, Yuzuru; Soda Mariko; et al. (2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity”. Mol. Cell. United States. 10 (1): 55—67. ISSN 1097-2765. PMID 12150907. doi:10.1016/S1097-2765(02)00583-X.
^ Nakamura, Toshinobu; Hinagata Jun-ichi; et al. (2002). „HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors”. Biochem. Biophys. Res. Commun. United States. 290 (2): 858—64. ISSN 0006-291X. PMID 11785981. doi:10.1006/bbrc.2001.6271.
^ Doong, H; Price J; et al. (2000). „CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70”. Oncogene. ENGLAND. 19 (38): 4385—95. ISSN 0950-9232. PMID 10980614. doi:10.1038/sj.onc.1203797.
^ Antoku, K; Maser R S; et al. (2001). „Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein”. Biochem. Biophys. Res. Commun. United States. 286 (5): 1003—10. ISSN 0006-291X. PMID 11527400. doi:10.1006/bbrc.2001.5512.
^ Pang, Qishen; Christianson Tracy A; et al. (2002). „The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC”. J. Biol. Chem. United States. 277 (51): 49638—43. ISSN 0021-9258. PMID 12397061. doi:10.1074/jbc.M209386200.
^ Reuter, Tanja Y; Medhurst Annette L; et al. (2003). „Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport”. Exp. Cell Res. United States. 289 (2): 211—21. ISSN 0014-4827. PMID 14499622. doi:10.1016/S0014-4827(03)00261-1.
^ Shi, Y; Mosser D D; Morimoto R I (1998). „Molecular chaperones as HSF1-specific transcriptional repressors”. Genes Dev. UNITED STATES. 12 (5): 654—66. ISSN 0890-9369. PMC 316571 . PMID 9499401.
^ Zhou, X; Tron V A; et al. (1998). „Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light”. J. Invest. Dermatol. UNITED STATES. 111 (2): 194—8. ISSN 0022-202X. PMID 9699716. doi:10.1046/j.1523-1747.1998.00266.x.
^ Ruchalski, Kathleen; Mao Haiping; et al. (2003). „HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells”. Am. J. Physiol., Cell Physiol. United States. 285 (6): C1483—93. ISSN 0363-6143. PMID 12930708. doi:10.1152/ajpcell.00049.2003.
^ Ravagnan, L; Gurbuxani S; et al. (2001). „Heat-shock protein 70 antagonizes apoptosis-inducing factor”. Nat. Cell Biol. England. 3 (9): 839—43. ISSN 1465-7392. PMID 11533664. doi:10.1038/ncb0901-839.

Literatura

Andersen JL, Planelles V (2005). „The role of Vpr in HIV-1 pathogenesis.”. Curr. HIV Res. 3 (1): 43—51. PMID 15638722. doi:10.2174/1570162052772988.
Zhao RY, Elder RT (2005). „Viral infections and cell cycle G2/M regulation.”. Cell Res. 15 (3): 143—9. PMID 15780175. doi:10.1038/sj.cr.7290279.
Zhao RY, Bukrinsky M, Elder RT (2005). „HIV-1 viral protein R (Vpr) & host cellular responses.”. Indian J. Med. Res. 121 (4): 270—86. PMID 15817944.
Muthumani K; Choo AY; Premkumar A; et al. (2006). „Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism.”. Cell Death Differ. 12. Suppl 1: 962—70. PMID 15832179. doi:10.1038/sj.cdd.4401583.
Grosz MD, Womack JE, Skow LC (1993). „Syntenic conservation of HSP70 genes in cattle and humans.”. Genomics. 14 (4): 863—8. PMID 1478667. doi:10.1016/S0888-7543(05)80106-5.
Veldscholte J; Berrevoets CA; Brinkmann AO; et al. (1992). „Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation.”. Biochemistry. 31 (8): 2393—9. PMID 1540595. doi:10.1021/bi00123a026.
Abravaya K, Myers MP, Murphy SP, Morimoto RI (1992). „The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression.”. Genes Dev. 6 (7): 1153—64. PMID 1628823. doi:10.1101/gad.6.7.1153.
Milner CM, Campbell RD (1990). „Structure and expression of the three MHC-linked HSP70 genes.”. Immunogenetics. 32 (4): 242—51. PMID 1700760. doi:10.1007/BF00187095.
Sargent CA, Dunham I, Trowsdale J, Campbell RD (1989). „Human major histocompatibility complex contains genes for the major heat shock protein HSP70.”. Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1968—72. PMC 286826 . PMID 2538825. doi:10.1073/pnas.86.6.1968.
Wu B, Hunt C, Morimoto R (1985). „Structure and expression of the human gene encoding major heat shock protein HSP70.”. Mol. Cell. Biol. 5 (2): 330—41. PMC 366716 . PMID 2858050.
Goate AM; Cooper DN; Hall C; et al. (1987). „Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis.”. Hum. Genet. 75 (2): 123—8. PMID 2880793. doi:10.1007/BF00591072.
Hickey E; Brandon SE; Sadis S; et al. (1986). „Molecular cloning of sequences encoding the human heat-shock proteins and their expression during hyperthermia.”. Gene. 43 (1-2): 147—54. PMID 3019832. doi:10.1016/0378-1119(86)90018-1.
Harrison GS; Drabkin HA; Kao FT; et al. (1987). „Chromosomal location of human genes encoding major heat-shock protein HSP70.”. Somat. Cell Mol. Genet. 13 (2): 119—30. PMID 3470951. doi:10.1007/BF01534692.
Drabent B, Genthe A, Benecke BJ (1987). „In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells.”. Nucleic Acids Res. 14 (22): 8933—48. PMC 311921 . PMID 3786141. doi:10.1093/nar/14.22.8933.
Hunt C, Morimoto RI (1985). „Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.”. Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6455—9. PMC 390735 . PMID 3931075. doi:10.1073/pnas.82.19.6455.
Liao J, Lowthert LA, Ghori N, Omary MB (1995). „The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner.”. J. Biol. Chem. 270 (2): 915—22. PMID 7529764. doi:10.1074/jbc.270.2.915.
Selkirk JK, Merrick BA, Stackhouse BL, He C (1995). „Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line.”. Appl. Theor. Electrophor. 4 (1): 11—8. PMID 7811761.
Furlini G; Vignoli M; Re MC; et al. (1994). „Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein.”. J. Gen. Virol. 75. (Pt 1) (1): 193—9. PMID 7906708. doi:10.1099/0022-1317-75-1-193.
Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene. 138 (1-2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Prapapanich V; Chen S; Toran EJ; et al. (1996). „Mutational analysis of the hsp70-interacting protein Hip.”. Mol. Cell. Biol. 16 (11): 6200—7. PMC 231623 . PMID 8887650.