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Glutation amid reduktaza
Glutation amid reduktaza
Identifikatori
EC broj	1.8.1.16
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Glutation amid reduktaza (EC 1.8.1.16, GAR) je enzim sa sistematskim imenom glutation amid:NAD⁺ oksidoreduktaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 glutation amid + NAD⁺

\rightleftharpoons

glutation amid disulfid + NADH + H⁺

Ovaj enzim je dimerni flavoprotein (FAD). On obnavlja glutation amid disulfid, koji se formira tokom redukcije peroksida enzimom EC 1.11.1.17 (glutation amid-zavisnom peroksidazom), nazad u glutationski amid (on katalizuje reakciju reverznom smeru od prikazanog).

Reference

^ Vergauwen, B., Pauwels, F., Jacquemotte, F., Meyer, T.E., Cusanovich, M.A., Bartsch, R.G. and Van Beeumen, J.J. (2001). „Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling”. J. Biol. Chem. 276: 20890—20897. PMID 11399772.
^ Vergauwen, B., Van Petegem, F., Remaut, H., Pauwels, F. and Van Beeumen, J.J. (2002). „Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile”. Acta Crystallogr. D Biol. Crystallogr. 58: 339—340. PMID 11807270.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Glutathione+amide+reductase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Vergauwen, B., Pauwels, F., Jacquemotte, F., Meyer, T.E., Cusanovich, M.A., Bartsch, R.G. and Van Beeumen, J.J. (2001). „Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling”. J. Biol. Chem. 276: 20890—20897. PMID 11399772.

[2] Vergauwen, B., Van Petegem, F., Remaut, H., Pauwels, F. and Van Beeumen, J.J. (2002). „Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile”. Acta Crystallogr. D Biol. Crystallogr. 58: 339—340. PMID 11807270.

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