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Glaucin
IUPAC ime
	(S)-5,6,6a,7-tetrahidro-1,2,9,10-tetrametoksi-6-metil-4H-dibenzo[de,g]hinolin
Klinički podaci
Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	475-81-0 ; 5630-11-5
ATC kod	none
PubChem	CID 16754
ChemSpider	15883
UNII	NU19306XA7
ChEMBL	CHEMBL228082
NIAID ChemDB	011385
Hemijski podaci
Formula	C21H25NO4
Molarna masa	355,428 g/mol
	SMILES CN1CCc2cc(c(c-3c2[C@@H]1Cc4c3cc(c(c4)OC)OC)OC)OC; ;
	InChI InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3/t15-/m0/s1 ; Key:RUZIUYOSRDWYQF-HNNXBMFYSA-N ;

Glaucin je alkaloid prisutan u nekoliko različitih vrsta biljki kao što su Glaucium flavum^[1], Glaucium oxylobum,^[2] Croton lechleri^[3] i Corydalis yanhusuo.^[4] On ima bronhodilatatorske i antiinflamatorne efekte, usled delovanja kao PDE4 inhibitor i blokator kalcijumovog kanala,^[5] i koristi se kao antitusik u nekim zemljama.^[6] Glaucin može da ima nuspojave poput sedacije, umora, i halucinogena dejstva karakterisana burnim vizuelnim prikazima,^[7]^[8] i odnedavno je zabeležena njegova upotreba kao droge.^[9]

Reference

^ G.B. Lapa; O.P. Sheichenko; A.G. Serezhechkin; O.N. Tolkachev (2004). „HPLC Determination of Glaucine in Yellow Horn Poppy Grass (Glaucium flavum Crantz)”. Pharmaceutical Chemistry Journal. 38 (1): 441—442. ISSN 0091-150X. S2CID 44040818. doi:10.1023/B:PHAC.0000048907.58847.c6. Приступљено 14. 6. 2009. „S-(+)-Glaucine (C₂₁H₂₅NO₄) is the main alkaloid component in the grass of yellow horn poppy (Glaucium luteum L., syn. Glaucium flavum Crantz) of the Papaveraceae family” Непознати параметар |name-list-style= игнорисан (помоћ)
^ Morteza-Semnani, K.; Amin, G.; Shidfar, M. R.; Hadizadeh, H.; Shafiee, A. (јул 2003). „Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum”. Fitoterapia. 74 (5): 493—6. PMID 12837370. doi:10.1016/s0367-326x(03)00113-8.
^ Milanowski, D. J.; Winter, R. E.; Elvin-Lewis, M. P.; Lewis, W. H. (јун 2002). „Geographic distribution of three alkaloid chemotypes of Croton lechleri”. Journal of Natural Products. 65 (6): 814—9. PMID 12088421. doi:10.1021/np000270v.
^ Xu, X. H.; Yu, G. D.; Wang, Z. T. (мај 2004). „Resource investigation and quality evaluation on wild Corydalis yanhusuo”. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 29 (5): 399—401. PMID 15706885.
^ Cortijo, J.; Villagrasa, V.; Pons, R.; Berto, L.; Martí-Cabrera, M.; Martinez-Losa, M.; Domenech, T.; Beleta, J.; Morcillo, E. J. (август 1999). „Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes”. British Journal of Pharmacology. 127 (7): 1641—51. PMC 1566148 . PMID 10455321. doi:10.1038/sj.bjp.0702702.
^ Rühle, K. H.; Criscuolo, D.; Dieterich, H. A.; Köhler, D.; Riedel, G. (мај 1984). „Objective evaluation of dextromethorphan and glaucine as antitussive agents”. British Journal of Clinical Pharmacology. 17 (5): 521—4. PMC 1463443 . PMID 6375709. doi:10.1111/j.1365-2125.1984.tb02384.x.
^ Rovinskiĭ, V. I. (септембар 1989). „A case of hallucinogen-like action of glaucine”. Klinicheskaia Meditsina. 67 (9): 107—8. PMID 2586025.
^ Rovinskiĭ, V. I. (2006). „Acute glaucine syndrome in the physician's practice: The clinical picture and potential danger”. Klinicheskaia Meditsina. 84 (11): 68—70. PMID 17243616.
^ Dargan, P. I.; Button, J.; Hawkins, L.; Archer, J. R.; Ovaska, H.; Lidder, S.; Ramsey, J.; Holt, D. W.; Wood, D. M. (мај 2008). „Detection of the pharmaceutical agent glaucine as a recreational drug”. European Journal of Clinical Pharmacology. 64 (5): 553—4. PMID 18204834. S2CID 21348503. doi:10.1007/s00228-007-0451-9.

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Spoljašnje veze

[1] G.B. Lapa; O.P. Sheichenko; A.G. Serezhechkin; O.N. Tolkachev (2004). „HPLC Determination of Glaucine in Yellow Horn Poppy Grass (Glaucium flavum Crantz)”. Pharmaceutical Chemistry Journal. 38 (1): 441—442. ISSN 0091-150X. S2CID 44040818. doi:10.1023/B:PHAC.0000048907.58847.c6. Приступљено 14. 6. 2009. „S-(+)-Glaucine (C₂₁H₂₅NO₄) is the main alkaloid component in the grass of yellow horn poppy (Glaucium luteum L., syn. Glaucium flavum Crantz) of the Papaveraceae family” Непознати параметар |name-list-style= игнорисан (помоћ)

[2] Morteza-Semnani, K.; Amin, G.; Shidfar, M. R.; Hadizadeh, H.; Shafiee, A. (јул 2003). „Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum”. Fitoterapia. 74 (5): 493—6. PMID 12837370. doi:10.1016/s0367-326x(03)00113-8.

[3] Milanowski, D. J.; Winter, R. E.; Elvin-Lewis, M. P.; Lewis, W. H. (јун 2002). „Geographic distribution of three alkaloid chemotypes of Croton lechleri”. Journal of Natural Products. 65 (6): 814—9. PMID 12088421. doi:10.1021/np000270v.

[4] Xu, X. H.; Yu, G. D.; Wang, Z. T. (мај 2004). „Resource investigation and quality evaluation on wild Corydalis yanhusuo”. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 29 (5): 399—401. PMID 15706885.

[5] Cortijo, J.; Villagrasa, V.; Pons, R.; Berto, L.; Martí-Cabrera, M.; Martinez-Losa, M.; Domenech, T.; Beleta, J.; Morcillo, E. J. (август 1999). „Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes”. British Journal of Pharmacology. 127 (7): 1641—51. PMC 1566148 . PMID 10455321. doi:10.1038/sj.bjp.0702702.

[6] Rühle, K. H.; Criscuolo, D.; Dieterich, H. A.; Köhler, D.; Riedel, G. (мај 1984). „Objective evaluation of dextromethorphan and glaucine as antitussive agents”. British Journal of Clinical Pharmacology. 17 (5): 521—4. PMC 1463443 . PMID 6375709. doi:10.1111/j.1365-2125.1984.tb02384.x.

[7] Rovinskiĭ, V. I. (септембар 1989). „A case of hallucinogen-like action of glaucine”. Klinicheskaia Meditsina. 67 (9): 107—8. PMID 2586025.

[8] Rovinskiĭ, V. I. (2006). „Acute glaucine syndrome in the physician's practice: The clinical picture and potential danger”. Klinicheskaia Meditsina. 84 (11): 68—70. PMID 17243616.

[9] Dargan, P. I.; Button, J.; Hawkins, L.; Archer, J. R.; Ovaska, H.; Lidder, S.; Ramsey, J.; Holt, D. W.; Wood, D. M. (мај 2008). „Detection of the pharmaceutical agent glaucine as a recreational drug”. European Journal of Clinical Pharmacology. 64 (5): 553—4. PMID 18204834. S2CID 21348503. doi:10.1007/s00228-007-0451-9.

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