Formiminotetrahidrofolatna ciklodeaminaza

Formiminotetrahidrofolatna ciklodeaminaza
Identifikatori
EC broj	4.3.1.4
CAS broj	2605038
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Formiminotetrahidrofolatna ciklodeaminaza (EC 4.3.1.4, 5-formimidoiltetrahidrofolatna amonijak-lijaza (ciklizacija)) je enzim sa sistematskim imenom 5-formimidoiltetrahidrofolat amonijak-lijaza (ciklizacija, formira 5,10-meteniltetrahidrofolat).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

5-formimidoiltetrahidrofolat ${\displaystyle \rightleftharpoons }$ 5,10-meteniltetrahidrofolat + NH₃

Kod eukariota, ovaj enzim je bifunkcionalan. On takođe deluje kao glutamat formimidoiltransferaza (EC 2.1.2.5).

Reference

1. Rabinowitz, J.C. & Pricer, W.E. (1956). „Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N¹⁰-formyltetrahydrofolic acid”. J. Am. Chem. Soc. 78: 5702—5704. 

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

• Formimidoyltetrahydrofolate+cyclodeaminase на US National Library of Medicine Medical Subject Headings (MeSH)