Dezoksicitidin kinaza

Dezoksicitidin kinaza
Identifikatori
EC broj	2.7.1.74
CAS broj	9039-45-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Dezoksicitidin kinaza (EC 2.7.1.74, dezoksicitidinska kinaza (fosforilacija), 2'-dezoksicitidinska kinaza, Ara-C kinaza, arabinofuranozilcitozinska kinaza, dezoksicitidin-citidinska kinaza) je enzim sa sistematskim imenom NTP:dezoksicitidin 5'-fosfotransferaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

NTP + dezoksicitidin ${\displaystyle \rightleftharpoons }$ NDP + dCMP

Citozin arabinozid može da deluje kao akceptor. Svi prirodni nukleozid trifosfati (izuzev dCTP) mogu da budu donori.

Reference

1. Durham, J.P. & Ives, D.H. (1970). „Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme”. J. Biol. Chem. 245: 2276—2284. PMID 5442271. 
2. Ives, D.H. & Durham, J.P. (1970). „Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme”. J. Biol. Chem. 245: 2285—2294. PMID 5462538. 
3. Kessel, D. (1968). „Properties of deoxycytidine kinase partially purified from L1210 cells”. J. Biol. Chem. 243: 4739—4744. PMID 5687717. 
4. Momparler, R.L. & Fischer, G.A. (1968). „Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside”. J. Biol. Chem. 243: 4298—4304. PMID 5684726. 

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

• Deoxycytidine+kinase на US National Library of Medicine Medical Subject Headings (MeSH)