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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Daktilizin
Daktilizin
Identifikatori
EC broj	3.4.24.60
CAS broj	139466-40-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Daktilizin (EC 3.4.24.60, endopeptidaza inaktivacije peptidnog hormona, PHIE) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza peptida sa najmanje šest ostataka, sa glomaznim hidrofobnim ostacima u P1' poziciji. Ispoljava preferenciju za hidrofobne doublete kao što su -Phe-Phe- i -Phe-Leu- u somatostatin-(1-14)-peptidu i dinorfin A-(1-6)-peptidu, respektivno

Ova endopeptidaza se izlučuje iz kože vodozemca Xenopus laevis.

Reference

^ Carvalho, K.M., Joudiou, C., Boussetta, H., Leseney, A.-M. and Cohen, P. (1992). „A peptide-hormone-inactivating endopeptidase in Xenopus laevis skin secretion”. Proc. Natl. Acad. Sci. USA. 89: 84—88. PMID 1729723.
^ Delporte, C., Carvalho, K.M., Leseney, A.-M., Winand, J., Christophe, J. and Cohen, P. (1992). „A new metallo-endopeptidase from human neuroblastoma NB-OK-1 cells which inactivates atrial natriuretic peptide by selective cleavage at the Ser¹²³-Phe¹²⁴ bond”. Biochem. Biophys. Res. Commun. 182: 158—164. PMID 1531011.
^ Joudiou, C., Carvalho, K.M., Camarao, G., Boussetta, H. and Cohen, P. (1993). „Characterization of the thermolysin-like cleavage of biologically active peptides by Xenopus laevis peptide hormone inactivating enzyme”. Biochemistry. 32: 5959—5966. PMID 8507636.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Dactylysin на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Carvalho, K.M., Joudiou, C., Boussetta, H., Leseney, A.-M. and Cohen, P. (1992). „A peptide-hormone-inactivating endopeptidase in Xenopus laevis skin secretion”. Proc. Natl. Acad. Sci. USA. 89: 84—88. PMID 1729723.

[2] Delporte, C., Carvalho, K.M., Leseney, A.-M., Winand, J., Christophe, J. and Cohen, P. (1992). „A new metallo-endopeptidase from human neuroblastoma NB-OK-1 cells which inactivates atrial natriuretic peptide by selective cleavage at the Ser¹²³-Phe¹²⁴ bond”. Biochem. Biophys. Res. Commun. 182: 158—164. PMID 1531011.

[3] Joudiou, C., Carvalho, K.M., Camarao, G., Boussetta, H. and Cohen, P. (1993). „Characterization of the thermolysin-like cleavage of biologically active peptides by Xenopus laevis peptide hormone inactivating enzyme”. Biochemistry. 32: 5959—5966. PMID 8507636.

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