DNK-metiltransferaza (citozin-N4-specifična)

DNK-metiltransferaza (citozin-N^4-specifična)
Identifikatori
EC broj	2.1.1.113
CAS broj	169592-50-1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

DNK-metiltransferaza (citozin-N⁴-specifična) (EC 2.1.1.113, modifikaciona metilaza, restrikciono-modifikacioni sistem, DNK(citozin-N⁴)metiltransferaza, Mtase (formira m4C), S-adenozil-L-metionin:DNK-citozin 4-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:DNK-citozin N⁴-metiltransferaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + DNK citozin ${\displaystyle \rightleftharpoons }$ S-adenozil-L-homocistein + DNK N⁴-metilcitozin

Ovao je velika grupa enzima, većina kojih ima sličnu specifičnost sa enzimima grupa EC 3.1.21.3, EC 3.1.21.4 i EC 3.1.21.5.

Reference

1. Kessler, C. & Manta, V. (1990). „Specificity of restriction endonucleases and DNA modification methyltransferases: a review”. Gene. 92: 1—248. PMID 2172084. 
2. Klimasauskas, S., Timinskas, A., Menkevicius, S., Butkiene, D., Butkus, V. and Janulaitis, A. (1989). „Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases”. Nucleic Acids Res. 17: 9823—9832. PMID 2690010. CS1 одржавање: Вишеструка имена: списак аутора (веза)
3. Roberts, R.J. (1990). „Restriction enzymes and their isoschizomers”. Nucleic Acids Res. 18: 2331—2365. PMID 2159140. 
4. Yuan, R. (1981). „Structure and mechanism of multifunctional restriction endonucleases”. Annu. Rev. Biochem. 50: 285—319. PMID 6267988. 

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

• Site-specific+DNA-methyltransferase+(cytosine-N4-specific) на US National Library of Medicine Medical Subject Headings (MeSH)