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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Atrolizin E
Atrolizin E
Identifikatori
EC broj	3.4.24.44
CAS broj	172306-51-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Atrolizin E (EC 3.4.24.44, Crotalus atrox metaloendopeptidaza e, hemoragi, ni toksin e) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje Asn³-Gln, Ser⁹-His i Ala¹⁴-Leu veza u lancu insulina B i Tyr¹⁴-Gln i Thr⁸-Ser u A lancu. Razlaganje tipa IV kolagena na Ala⁷³-Gln u alfa1(IV) i na Gly⁷-Leu u alfa2(IV)

Ova nehemoragična endopeptidaza je prisutna u venumu zvečarke Crotalus atrox.

Reference

^ Bjarnason, J.B. & Tu, A.T. (1978). „Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry. 17: 3395—3404. PMID 210790.
^ Bjarnason, J.B. & Fox, J.W. (1983). „Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox)”. Biochemistry. 22: 3770—3778. PMID 6351911.
^ Baramova, E.N., Shannon, J.D., Bjarnason, J.B. and Fox, J.W. (1990). „Identification of the cleavave sites by a hemorrhagic metalloproteinase in type IV collagen”. Matrix. 10: 91—97. PMID 2374521.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Atrolysin+E на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Bjarnason, J.B. & Tu, A.T. (1978). „Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry. 17: 3395—3404. PMID 210790.

[2] Bjarnason, J.B. & Fox, J.W. (1983). „Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox)”. Biochemistry. 22: 3770—3778. PMID 6351911.

[3] Baramova, E.N., Shannon, J.D., Bjarnason, J.B. and Fox, J.W. (1990). „Identification of the cleavave sites by a hemorrhagic metalloproteinase in type IV collagen”. Matrix. 10: 91—97. PMID 2374521.

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