Alkilgliceron-fosfat sintaza

Alkilgliceron-fosfat sintaza
Identifikatori
EC broj	2.5.1.26
CAS broj	102484-74-2&title= 64060-42-0, 102484-74-2
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Alkilgliceron-fosfat sintaza (EC 2.5.1.26, alkildihidroksiacetonfosfatna sintaza, alkildihidroksiaceton fosfatna sintetaza, alkil DHAP sintetaza, alkil-DHAP, dihidroksiaceton-fosfatna aciltransferaza, DHAP-AT) je enzim sa sistematskim imenom 1-acil-gliceron-3-fosfat:dugolančani-alkohol O-3-fosfo-2-oksopropaniltransferaza.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-acil-gliceron 3-fosfat + dugolančani alkohol ${\displaystyle \rightleftharpoons }$ alkil-gliceron 3-fosfat + dugolančani kiselinski anion

Estarski vezana masna kiselina supstrata se odvaja i zamenjuje dugolančanim alkoholom etarski vezanim.

Reference

1. Brown, A.J. & Snyder, F. (1982). „Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism”. J. Biol. Chem. 257: 8835—8839. PMID 7096336. 
2. Wykle, R.L., Piantadosi, C. and Snyder, F. (1972). „The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor”. J. Biol. Chem. 247: 2944—2948. PMID 4401994. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

• Alkylglycerone-phosphate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)