Aldos-2-ulozna dehidrataza

Aldos-2-ulozna dehidrataza
Identifikatori
EC broj	4.2.1.110
CAS broj	101920-80-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Aldos-2-ulozna dehidrataza (EC 4.2.1.110, piranozonska dehidrataza, AUDH, 1,5-anhidro-D-fruktoza dehidrataza (formira mikrotecin)) je enzim sa sistematskim imenom 1,5-anhidro-D-fruktoza hidrolijaza (formira mikrotecin).^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

1,5-anhidro-D-fruktoza ${\displaystyle \rightleftharpoons }$ 2-hidroksi-2-(hidroksimetil)-2H-piran-3(6H)-on + H₂O (sveukupna reakcija)

(1a) 1,5-anhidro-D-fruktoza ${\displaystyle \rightleftharpoons }$ 1,5-anhidro-4-dezoksi-D-glicero-heks-3-en-2-uloza + H₂O

(1b) 1,5-anhidro-4-dezoksi-D-glicero-heks-3-en-2-uloza ${\displaystyle \rightleftharpoons }$ 2-hidroksi-2-(hidroksimetil)-2H-piran-3(6H)-on

Ovaj enzim katalizuje dva koraka u reakcionom putu degradacije glikogena i skroba.

Reference

1. Yu, S. & Fiskesund, R. (2006). „The anhydrofructose pathway and its possible role in stress response and signaling”. Biochim. Biophys. Acta. 1760: 1314—1322. PMID 16822618. 
2. Yu, S. (2005). „Enzymatic description of the anhydrofructose pathway of glycogen degradation. II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate”. Biochim. Biophys. Acta. 1723: 63—73. PMID 15716041. 
3. Broberg, A., Kenne, L. and Pedersén, M. (1996). „Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose”. Phytochemistry. 41: 151—154. CS1 одржавање: Вишеструка имена: списак аутора (веза)
4. Gabriel, J., Volc, J., Sedmera, P., Daniel, G. and Kubátová, E. (1993). „Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products”. Arch. Microbiol. 160: 27—34. PMID 8352649. CS1 одржавање: Вишеструка имена: списак аутора (веза)
5. Yu, S., Refdahl, C. and Lundt, I. (2004). „Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and α-1,4-glucan lyase in the fungus Anthracobia melaloma”. Biochim. Biophys. Acta. 1672: 120—129. PMID 15110094. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

• Aldos-2-ulose+dehydratase на US National Library of Medicine Medical Subject Headings (MeSH)