Adenozilkobinamid-GDP ribazoltransferaza

Adenozilkobinamid-GDP ribazoltransferaza
Identifikatori
EC broj	2.7.8.26
CAS broj	137672-85-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Adenozilkobinamid-GDP ribazoltransferaza (EC 2.7.8.26, CobS, kobalaminska sintaza, kobalamin-5'-fosfat sintaza, kobalamin (5'-fosfat) sintaza) je enzim sa sistematskim imenom adenozilkobinamid-GDP:alfa-ribazol ribazoltransferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) adenozilkobinamid-GDP + alfa-ribazol ${\displaystyle \rightleftharpoons }$ GMP + adenozilkobalamin

(2) adenozilkobinamid-GDP + alfa-ribazol 5'-fosfat ${\displaystyle \rightleftharpoons }$ GMP + adenozilkobalamin 5'-fosfat

Kod Salmonella typhimurium LT2, pri anaerobnim uslovima, CobU (EC 2.7.7.62 i EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) i CobS (EC 2.7.8.26) katalizuje reakcije biosinteze nukleotidne petlje, kojima se konvertuje adenozilkobinamid (AdoCbi) u adenozilkobalamin (AdoCbl).

Reference

1. Maggio-Hall, L.A. & Escalante-Semerena, J.C. (1999). „In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes”. Proc. Natl. Acad. Sci. USA. 96: 11798—11803. PMID 10518530. 
2. Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B₁₂)”. Nat. Prod. Rep. 19: 390—412. PMID 12195810. CS1 одржавање: Вишеструка имена: списак аутора (веза)
3. Cameron, B., Blanche, F., Rouyez, M.C., Bisch, D., Famechon, A., Couder, M., Cauchois, L., Thibaut, D., Debussche, L. and Crouzet, J. (1991). „Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5′-phosphate) synthase”. J. Bacteriol. 173: 6066—6073. PMID 1917841. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

• Adenosylcobinamide-GDP+ribazoletransferase на US National Library of Medicine Medical Subject Headings (MeSH)