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3-ketosteroid 9alfa-monooksigenaza
3-ketosteroid 9alfa-monooksigenaza
Identifikatori
EC broj	1.14.13.142
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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3-ketosteroid 9alfa-monooksigenaza (EC 1.14.13.142, KshAB, 3-ketosteroid 9alfa-hidroksilaza) je enzim sa sistematskim imenom androsta-1,4-dien-3,17-dion,NADH:kiseonik oksidoreduktaza (9alfa-hidroksilacija).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

androsta-1,4-dien-3,17-dion + NADH + H⁺ + O₂

\rightleftharpoons

9alfa-hidroksiandrosta-1,4-dien-3,17-dion + NAD⁺ + H₂O

Ovaj enzim učestvuje u holesterol degradaciji u nekoliko bakterijskih patogena, kao što je Mycobakterija tuberculosis.

Reference

^ Petrusma, M., Dijkhuizen, L. and van der Geize, R. (2009). „Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9α-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity”. Appl. Environ. Microbiol. 75: 5300—5307. PMID 19561185.
^ Capyk, J.K., D'Angelo, I., Strynadka, N.C. and Eltis, L.D. (2009). „Characterization of 3-ketosteroid 9α-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis”. J. Biol. Chem. 284: 9937—9946. PMID 19234303.
^ Capyk, J.K., Casabon, I., Gruninger, R., Strynadka, N.C. and Eltis, L.D. (2011). „Activity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis”. J. Biol. Chem.: —. PMID 21987574.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

3-ketosteroid+9alpha-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Petrusma, M., Dijkhuizen, L. and van der Geize, R. (2009). „Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9α-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity”. Appl. Environ. Microbiol. 75: 5300—5307. PMID 19561185.

[2] Capyk, J.K., D'Angelo, I., Strynadka, N.C. and Eltis, L.D. (2009). „Characterization of 3-ketosteroid 9α-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis”. J. Biol. Chem. 284: 9937—9946. PMID 19234303.

[3] Capyk, J.K., Casabon, I., Gruninger, R., Strynadka, N.C. and Eltis, L.D. (2011). „Activity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis”. J. Biol. Chem.: —. PMID 21987574.

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