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2,6-Dihidroksipseudooksinikotinska hidrolaza
2,6-Dihidroksipseudooksinikotinska hidrolaza
Identifikatori
EC broj	3.7.1.19
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

2,6-Dihidroksipseudooksinikotinska hidrolaza (EC 3.7.1.19) je enzim sa sistematskim imenom 1-(2,6-dihidroksipiridin-3-il)-4-(metilamino)butan-1-on hidrolaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-(2,6-dihidroksipiridin-3-il)-4-(metilamino)butan-1-on + H₂O

\rightleftharpoons

2,6-dihidroksipiridin + 4-metilaminobutanoat

Ovaj enzim je izolovan iz zemljišne bakterije Arthrobacter nikotinovorans.

Reference

^ Gherna, R.L., Richardson, S.H. and Rittenberg, S.C. (1965). „The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine”. J. Biol. Chem. 240: 3669—3674. PMID 5835946.
^ Sachelaru, P., Schiltz, E., Igloi, G.L. and Brandsch, R. (2005). „An α/β-fold C–C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans”. J. Bacteriol. 187: 8516—8519. PMID 16321959.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

2,6-dihydroxypseudooxynicotine+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Gherna, R.L., Richardson, S.H. and Rittenberg, S.C. (1965). „The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine”. J. Biol. Chem. 240: 3669—3674. PMID 5835946.

[2] Sachelaru, P., Schiltz, E., Igloi, G.L. and Brandsch, R. (2005). „An α/β-fold C–C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans”. J. Bacteriol. 187: 8516—8519. PMID 16321959.

[1]

[2]