1-Pirolin-4-hidroksi-2-karboksilatna deaminaza

1-Pirolin-4-hidroksi-2-karboksilatna deaminaza
Identifikatori
EC broj	3.5.4.22
CAS broj	9054-77-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

1-Pirolin-4-hidroksi-2-karboksilatna deaminaza (EC 3.5.4.22, HPC deaminaza) je enzim sa sistematskim imenom 1-pirolidin-4-hidroksi-2-karboksilat aminohidrolaza (deciklizacija).^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-pirolidin-4-hidroksi-2-karboksilat + H₂O ${\displaystyle \rightleftharpoons }$ 2,5-dioksopentanoat + NH₃

Reference

1. Singh, R.M.M. & Adams, E. (1965). „Enzymatic deamination of Δ¹-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (α-ketoglutaric semialdehyde)”. J. Biol. Chem. 240: 4344—4351. PMID 5845838. 
2. Singh, R.M.M. & Adams, E. (1965). „Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline”. J. Biol. Chem. 240: 4352—4356. PMID 5845839. 

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

• 1-pyrroline-4-hydroxy-2-carboxylate+deaminase на US National Library of Medicine Medical Subject Headings (MeSH)