Río Hondo (Spanish for "deep river") or Hondo River may be:
- Río Hondo, Zacapa, a municipality in the Guatemalan department of Zacapa
- Rio Hondo (Belize), a river that is much of the border between Belize and Mexico
- Rio Hondo (California), a tributary of the Los Angeles River in the U.S. state of California
- Rio Hondo, a barrio in Consolación del Sur, Cuba
- Rio Hondo (crater), a named impact crater on the asteroid 951 Gaspra
- Rio Hondo (Northern New Mexico), a river in the northern part of the U.S. state of New Mexico
- Rio Hondo (Southern New Mexico), a river in the southern part of the U.S. state of New Mexico
- Rio Hondo, a barrio in Zamboanga City, Philippines
- Rio Hondo (Puerto Rico), a river in the U.S. territory of Puerto Rico
- Rio Hondo, Texas, a township in the U.S. state of Texas
- Termas de Río Hondo, a city in the province of Santiago del Estero, Argentina
