Merkel-cell carcinoma (MCC) is a rare and aggressive skin cancer happening in about 3 per 1,000,000 population.[ 1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin.[ 2]
Reasons why the cancer would form is because of Merkel cell polyomavirus (MCPyV or MCV), a weakened immune system , and exposure to ultraviolet radiation .[ 3] [ 4]
Merkel-cell carcinoma usually shows up on the head, neck, perianal and eyelid.[ 5] It is more common in elderly people.
References
↑ "Merkel-cell carcinima" . Dynamed . Archived from the original on 2020-02-19. Retrieved 2019-11-11 .
↑ Dermatology . Bolognia, Jean., Jorizzo, Joseph L., Rapini, Ronald P. (2nd ed.). St. Louis, MO: Mosby/Elsevier. 2008. ISBN 978-1-4160-2999-1 . OCLC 212399895 .{{cite book }}
: CS1 maint: others (link )
↑ Kervarrec, Thibault; Samimi, Mahtab; Guyétant, Serge; Sarma, Bhavishya; Chéret, Jérémy; Blanchard, Emmanuelle; Berthon, Patricia; Schrama, David; Houben, Roland; Touzé, Antoine (10 June 2019). "Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review" . Frontiers in Oncology . 9 : 451. doi :10.3389/fonc.2019.00451 . PMC 6579919 . PMID 31245285 .
↑ Rotondo, John Charles; Bononi, Ilaria; Puozzo, Andrea; Govoni, Marcello; Foschi, Valentina; Lanza, Giovanni; Gafà, Roberta; Gaboriaud, Pauline; Touzé, Françoise Antoine; Selvatici, Rita; Martini, Fernanda; Tognon, Mauro (15 July 2017). "Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF" . Clinical Cancer Research . 23 (14): 3929–3934. doi :10.1158/1078-0432.CCR-16-2899 . PMID 28174236 .
↑ Patterson, James W. (James Willis), 1946- (2014-12-07). Weedon's skin pathology . Hosler, Gregory A. (Fourth ed.). [Edinburgh?]. ISBN 978-0-7020-6200-1 . OCLC 900724639 . {{cite book }}
: CS1 maint: location missing publisher (link ) CS1 maint: multiple names: authors list (link ) CS1 maint: numeric names: authors list (link )