Don Carlos is an opera by Giuseppe Verdi, also known as Don Carlo.
Don Carlos or Don Carlo may also refer to:
- People
- Carlo Gesualdo (1566–1613), also known as Don Carlo Gesualdo, Italian music composer, murderer
- Don Carlos (basketball), American basketball player
- Carlos, Prince of Asturias (1545–1568)
- Don Carlos (1788–1855), Infante Carlos, Count of Molina
- Don Carlos Hugo (born 1930), Carlos Hugo of Bourbon, Duke of Parma
- Don Carlos (musician) (fl. late 20th century), Jamaican singer
- Don Carlos Smith, brother of Latter Day Saint leader Joseph Smith, Jr.
- Other