D'Amelio's career began after her sister Charli gained popularity on TikTok. Dixie D'Amelio also began posting on TikTok.[1] She is the 7th most-followed individual on TikTok. In 2020, she starred in the YouTube web series Attaway General.
D'Amelio's acting career includes appearing on the Brat TV series Attaway General. D'Amelio released her first single, "Be Happy" in 2020. The song has received more than 55.6 million streams on Spotify.
She signed a record deal with L.A. Reid's label HitCo Entertainment. Forbes published a report in August 2020 revealing D'Amelio earned $2.9 million in the last year through June from loads of her sponsorship deals and merchandise, making her the third highest-earning TikTok star.
D'Amelio released her second single, "One Whole Day" with Wiz Khalifa.