In the 2009 NBA Draft, the Clippers chose him with the first pick. However, Griffin broke a kneecap during the preseason and missed the entire 2009-2010 season.[4] He finally played his first regular season NBA game on October 27, 2010. Griffin scored 20 points and had 14 rebounds, although the Clippers lost to the Portland Trail Blazers, 98-88.[5]
Griffin quickly became known as a hard working player and a good dunker. He was chosen to be in the slam dunk contest during the 2011 NBA All-Star Weekend, and was also chosen to play in the 2011 NBA All-Star Game.[6]
On April 16, 2024, Griffin announced that he was retiring from playing professional basketball.[7]