Neuromedin S

Neuromedin S
Identifikatori
Simbol NMS
Entrez 129521
HUGO 32203
Drugi podaci
Lokus Hromozom 2 q11.2

Neuromedin S je neuropeptid sa 36 aminokiselina nađen u mozgu ljudi i drugih sisara. On nastaje u suprahiazmatičnom jezgru hipotalamusa, i srodan je sa neuromedinom U. Smatra se da on učestvuje u regulaciji cirkadijalnog ritma i da deluje kao supresant apetita,[1][2][3][4][5] kao i regulator oslobađanja nekoliko drugih peptidnih hormona među kojima su vazopresin,[6] Luteinizirajući hormon,[7] i oksitocin.[8]

Povezano

Literatura

  1. ↑ Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M, Kangawa K (January 2005). „Identification of neuromedin S and its possible role in the mammalian circadian oscillator system”. The EMBO Journal 24 (2): 325–35. DOI:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449. 
  2. ↑ Mori K, Miyazato M, Kangawa K (2008). „Neuromedin S: discovery and functions”. Results and Problems in Cell Differentiation 46: 201–12. DOI:10.1007/400_2007_054. PMID 18214396. 
  3. ↑ Novak CM (July 2009). „Neuromedin S and U”. Endocrinology 150 (7): 2985–7. DOI:10.1210/en.2009-0448. PMC 2703548. PMID 19549882. 
  4. ↑ Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ (July 2009). „The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)”. Endocrinology 150 (7): 3101–9. DOI:10.1210/en.2008-1772. PMC 2703546. PMID 19324999. 
  5. ↑ Mitchell J, Maguire J, Davenport A (June 2009). „Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S”. British Journal of Pharmacology 158 (1): 87–103. DOI:10.1111/j.1476-5381.2009.00252.x. PMC 2795236. PMID 19519756. 
  6. ↑ Sakamoto T, Mori K, Nakahara K, Miyazato M, Kangawa K, Sameshima H, Murakami N (September 2007). „Neuromedin S exerts an antidiuretic action in rats”. Biochemical and Biophysical Research Communications 361 (2): 457–61. DOI:10.1016/j.bbrc.2007.07.036. PMID 17645872. 
  7. ↑ Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, Navarro VM, Pineda R, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M (February 2007). „Neuromedin s as novel putative regulator of luteinizing hormone secretion”. Endocrinology 148 (2): 813–23. DOI:10.1210/en.2006-0636. PMID 17110433. 
  8. ↑ Sakamoto T, Mori K, Miyazato M, Kangawa K, Sameshima H, Nakahara K, Murakami N (October 2008). „Involvement of neuromedin S in the oxytocin release response to suckling stimulus”. Biochemical and Biophysical Research Communications 375 (1): 49–53. DOI:10.1016/j.bbrc.2008.07.124. PMID 18675786. 

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