KoA-glutation reduktaza

KoA-glutation reduktaza
Identifikatori
EC broj	1.8.1.10
CAS broj	37256-33-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

KoA-glutation reduktaza (EC 1.8.1.10, koenzim A glutation disulfidna reduktaza, NADPH-zavisna koenzim A-SS-glutationska reduktaza, koenzim A disulfid-glutationska reduktaza, NADPH:KoA-glutationska oksidoreduktaza) je enzim sa sistematskim imenom glutation:NADP⁺ oksidoreduktaza (KoA-acilacija).^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

KoA + glutation + NADP⁺ ${\displaystyle \rightleftharpoons }$ KoA-glutation + NADPH + H⁺

Ovaj enzim je flavoprotein. Supstrat je mešoviti disulfid.

Reference

1. Ondarza, R.N., Abney, R. and López-Colomé, A.M. (1969). „Characterization of a NADPH-dependent coenzyme A-SS-glutathione reductase from yeast”. Biochim. Biophys. Acta 191: 239-248. PMID 4390951. 
2. Ondarza, R.N., Escamilla, E., Gutierrez, J. and De la Chica, G. (1974). „CoAS-Sglutathione and GSSG reductases from rat liver. Two disulfide oxidoreductase activities in one protein entity”. Biochim. Biophys. Acta 341: 162-171. PMID 4151341. 
3. Carlberg, I. and Mannervik, B. (1977). „Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione”. Biochim. Biophys. Acta 484: 268-274. PMID 334266. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH CoA-glutathione+reductase