Farmakokinetika, skraćeno PK, (od starogrčkogpharmakon "lek" i kinetikos "vezano za kretanje") je grana farmakologije koja se bavi izučavanjem promena supstanci doziranih u žive organizme. Supstance od interesa su farmaceutski agensi, hormoni, nutrijenti, i toksini. Ona pokužava da otkrije sudbinu leka od momenta njegovog unosa do tačke u kojoj je kompletno eliminisan iz tela.
Farmakokinetika se može jednostavno definisati kao to što telo radi leku, dok je farmakodinamika usredsređena na to što lek radi telu.[1]
Farmakokinetika opisuje kako telo deluje na specifični lek nakon doziranja putem mehanizama apsorpcije i distribucije, kao i hemijske promene supstane u telu (e.g. posredstvom metaboličkih enzima kao što su enzimicitohrom P450 ili glukuronoziltransferaza), i efekte i puteve izlučivanja metabolita leka.[2] Farmakokinetička svojstva leka mogu da budu uslovljena faktorima poput mesta administriranja i doze leka. Ti faktori mogu da utiču na brzinu apsorpcije.[3] Farmakokinetika se često studira zajedno sa farmakodinamikom.
↑Pharmacokinetics. (2006). In Mosby's Dictionary of Medicine, Nursing, & Health Professions. Philadelphia, PA: Elsevier Health Sciences. Retrieved December 11, 2008, from http://www.credoreference.com/entry/6686418
↑Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN0-7295-3664-5.
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