18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza

18S rRNK (adenin^1779-N^6/adenin^1780-N^6)-dimetiltransferaza
Identifikatori
EC broj	2.1.1.183
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

18S rRNK (adenin¹⁷⁷⁹-N⁶/adenin¹⁷⁸⁰-N⁶)-dimetiltransferaza (EC 2.1.1.183, 18S rRNK dimetilaza Dim1p, Dim1p, ScDim1, m2(6)A dimetilaza, KIDIM1) je enzim sa sistematskim imenom S-adenozil-L-metionin:18S rRNK (adenin¹⁷⁷⁹-N⁶/adenin¹⁷⁸⁰-N⁶)-dimetiltransferaza.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

4 S-adenozil-L-metionin + adenin¹⁷⁷⁹/adenin¹⁷⁸⁰ u 18S rRNK ${\displaystyle \rightleftharpoons }$ 4 S-adenozil-L-homocistein + N⁶-dimetiladenin¹⁷⁷⁹/N⁶-dimetiladenin¹⁷⁸⁰ u 18S rRNK

DIM1 učestvuje u pre-rRNK transformacijama.

Reference

1. Lafontaine, D., Vandenhaute, J. and Tollervey, D. (1995). „The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast”. Genes Dev. 9: 2470-2481. PMID 7590228. 
2. Lafontaine, D.L., Preiss, T. and Tollervey, D. (1998). „Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis”. Mol. Cell Biol. 18: 2360-2370. PMID 9528805. 
3. Pulicherla, N., Pogorzala, L.A., Xu, Z., O'Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Sia, E.A., Culver, G.M. and Rife, J.P. (2009). „Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases”. J. Mol. Biol. 391: 884-893. PMID 19520088. 
4. Lafontaine, D., Delcour, J., Glasser, A.L., Desgres, J. and Vandenhaute, J. (1994). „The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3′-terminal loop of 18 S rRNA is essential in yeast”. J. Mol. Biol. 241: 492-497. PMID 8064863. 
5. O'Farrell, H.C., Pulicherla, N., Desai, P.M. and Rife, J.P. (2006). „Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution”. RNA 12: 725-733. PMID 16540698. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 18S+rRNA+(adenine1779-N6/adenine1780-N6)-dimethyltransferase