Гетеротетрамер

Гетеротерамерный белок гемоглобин состоит из четырёх субъединиц двух типов (окрашены красным и синим).

Гетеротетраме́р — четвертичная структура белка в которой белковый комплекс состоит из четырёх не идентичных и не ковалентно связанных субъединиц[1]. Гомотетрамер содержит четыре идентичные субъединицы[2].

В качестве примера можно привести гемоглобин, NMDA-рецептор, некоторые аквапорины[3], некоторые AMPA-рецепторы, а также некоторые ферменты[4].

Очистка гетеротетрамеров

Для очистки гетеротетрамерных белков весьма полезна ионообменная хроматография, которая позволяет выделить определённые комплексы, как в зависимости от числа, так и от положения заряженных полипептидов[5][6]. Также для их очистки может применяться аффинная хроматография с иммобилизованными ионами никеля[7].

Примечания

  1. ↑ GO term: protein heterotetramerization. YeastGenome. Дата обращения: 14 мая 2011. Архивировано из оригинала 27 сентября 2011 года.
  2. ↑ GO term: protein homotetramerization. YeastGenome. Дата обращения: 14 мая 2011. Архивировано из оригинала 27 сентября 2011 года.
  3. ↑ Neely John D; Christensen Birgitte M; Nielsen Søren; Agre Peter. Heterotetrameric Compositio of Aquaporin-4 Water Channels (англ.) // Biochemistry : journal. — 1999. — 1 August (vol. 38, no. 34). — P. 11156—11163. — doi:10.1021/bi990941s. — PMID 10460172.
  4. ↑ Chang T.-H; Hsieh F.-L; Ko T.-P; Teng K.-H; Liang P.-H; Wang A. H.-J. Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation (англ.) // Plant Cell : journal. — 2010. — 5 February (vol. 22, no. 2). — P. 454—467. — doi:10.1105/tpc.109.071738. — PMID 20139160. — PMC 2845413.
  5. ↑ Sakash, J.B.; Kantrowitz, E.R. The contribution of individual interchain interactions to the stabilization of the T and R states of Escherichia coli aspartate transcarbamoylase. (англ.) // J Biol Chem : journal. — 2000. — Vol. 275, no. 37. — P. 28701—28707. — doi:10.1074/jbc.M005079200. — PMID 10875936.
  6. ↑ Fairhead, M. Plug-and-Play Pairing via Defined Divalent Streptavidins. (англ.) // J Mol Biol[англ.] : journal. — 2013. — Vol. 426, no. 1. — P. 199—214. — doi:10.1016/j.jmb.2013.09.016. — PMID 24056174.
  7. ↑ Howarth, Mark; Chinnapen, Daniel J-F; Gerrow, Kimberly; Dorrestein, Pieter C; Grandy, Melanie R; Kelleher, Neil L; El-Husseini, Alaa; Ting, Alice Y. A monovalent streptavidin with a single femtomolar biotin binding site (англ.) // Nature Methods : journal. — 2006. — Vol. 3, no. 4. — P. 267—273. — doi:10.1038/nmeth861. — PMID 16554831. — PMC 2576293.

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