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GSK3B (glycogen synthase kinase 3 beta) é uma enzima que em humanos é codificada pelo gene GSK3B.

Interações

Interage com CTNNB1,^[1]^[2] SGK3,^[3] TSC2,^[4]^[5] AR,^[6] MUC1,^[7]^[8] AXIN1,^[9]^[4] PRKAR2A,^[10] AKAP11,^[10] DNM1L,^[11] P53,^[12] AXIN2,^[13]^[14] NOTCH2,^[15] SMAD3^[16] e NOTCH1.^[17]

Referências

↑ Davies, G; Jiang W G, Mason M D (2001). «The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer». Greece. Int. J. Oncol. 18 (4): 843–7. ISSN 1019-6439. PMID 11251183
↑ Kishida, S; Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A (1999). «DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability». UNITED STATES. Mol. Cell. Biol. 19 (6): 4414–22. ISSN 0270-7306. PMC 104400. PMID 10330181
↑ Dai, Fangyan; Yu Long, He Hua, Chen Yongjing, Yu Jianqiang, Yang Yumei, Xu YueFang, Ling Wenhai, Zhao Shouyuan (2002). «Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction». United States. Biochem. Biophys. Res. Commun. 293 (4): 1191–6. ISSN 0006-291X. PMID 12054501. doi:10.1016/S0006-291X(02)00349-2
↑ ^a ^b Mak, Baldwin C; Takemaru Ken-Ichi, Kenerson Heidi L, Moon Randall T, Yeung Raymond S (2003). «The tuberin-hamartin complex negatively regulates beta-catenin signaling activity». United States. J. Biol. Chem. 278 (8): 5947–51. ISSN 0021-9258. PMID 12511557. doi:10.1074/jbc.C200473200
↑ Inoki, Ken; Ouyang Hongjiao, Zhu Tianqing, Lindvall Charlotta, Wang Yian, Zhang Xiaojie, Yang Qian, Bennett Christina, Harada Yuko, Stankunas Kryn, Wang Cun-Yu, He Xi, MacDougald Ormond A, You Ming, Williams Bart O, Guan Kun-Liang (2006). «TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth». United States. Cell. 126 (5): 955–68. ISSN 0092-8674. PMID 16959574. doi:10.1016/j.cell.2006.06.055
↑ Wang, Liang; Lin Hui-Kuan, Hu Yueh-Chiang, Xie Shaozhen, Yang Lin, Chang Chawnshang (2004). «Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells». United States. J. Biol. Chem. 279 (31): 32444–52. ISSN 0021-9258. PMID 15178691. doi:10.1074/jbc.M313963200
↑ Li, Y; Bharti A, Chen D, Gong J, Kufe D (1998). «Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin». UNITED STATES. Mol. Cell. Biol. 18 (12): 7216–24. ISSN 0270-7306. PMC 109303. PMID 9819408
↑ Li, Y; Kuwahara H, Ren J, Wen G, Kufe D (2001). «The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin». United States. J. Biol. Chem. 276 (9): 6061–4. ISSN 0021-9258. PMID 11152665. doi:10.1074/jbc.C000754200
↑ Nakamura, T; Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T (1998). «Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level». ENGLAND. Genes Cells. 3 (6): 395–403. ISSN 1356-9597. PMID 9734785. doi:10.1046/j.1365-2443.1998.00198.x
↑ ^a ^b Tanji, Chie; Yamamoto Hideki, Yorioka Noriaki, Kohno Nobuoki, Kikuchi Kunimi, Kikuchi Akira (2002). «A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta». United States. J. Biol. Chem. 277 (40): 36955–61. ISSN 0021-9258. PMID 12147701. doi:10.1074/jbc.M206210200
↑ Hong, Y R; Chen C H, Cheng D S, Howng S L, Chow C C (1998). «Human dynamin-like protein interacts with the glycogen synthase kinase 3beta». UNITED STATES. Biochem. Biophys. Res. Commun. 249 (3): 697–703. ISSN 0006-291X. PMID 9731200. doi:10.1006/bbrc.1998.9253
↑ Watcharasit, Piyajit; Bijur Gautam N, Zmijewski Jaroslaw W, Song Ling, Zmijewska Anna, Chen Xinbin, Johnson Gail V W, Jope Richard S (2002). «Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage». United States. Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7951–5. ISSN 0027-8424. PMC 123001. PMID 12048243. doi:10.1073/pnas.122062299
↑ von Kries, J P; Winbeck G, Asbrand C, Schwarz-Romond T, Sochnikova N, Dell'Oro A, Behrens J, Birchmeier W (2000). «Hot spots in beta-catenin for interactions with LEF-1, conductin and APC». UNITED STATES. Nat. Struct. Biol. 7 (9): 800–7. ISSN 1072-8368. PMID 10966653. doi:10.1038/79039
↑ Schwarz-Romond, Thomas; Asbrand Christian, Bakkers Jeroen, Kühl Michael, Schaeffer Hans-Joerg, Huelsken Jörg, Behrens Jürgen, Hammerschmidt Matthias, Birchmeier Walter (2002). «The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling». United States. Genes Dev. 16 (16): 2073–84. ISSN 0890-9369. PMC 186448. PMID 12183362. doi:10.1101/gad.230402
↑ Espinosa, Lluís; Inglés-Esteve Julia, Aguilera Cristina, Bigas Anna (2003). «Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways». United States. J. Biol. Chem. 278 (34): 32227–35. ISSN 0021-9258. PMID 12794074. doi:10.1074/jbc.M304001200
↑ Guo, Xing; Ramirez Alejandro, Waddell David S, Li Zhizhong, Liu Xuedong, Wang Xiao-Fan (2008). «Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling». United States. Genes Dev. 22 (1): 106–20. ISSN 0890-9369. PMC 2151009. PMID 18172167. doi:10.1101/gad.1590908
↑ Foltz, Daniel R; Santiago Michelle C, Berechid Bridget E, Nye Jeffrey S (2002). «Glycogen synthase kinase-3beta modulates notch signaling and stability». England. Curr. Biol. 12 (12): 1006–11. ISSN 0960-9822. PMID 12123574. doi:10.1016/S0960-9822(02)00888-6

Bibliografia

Turenne G, Price B (2001). «Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity». BMC Cell Biol. 2. 12 páginas. PMC 35361. PMID 11483158. doi:10.1186/1471-2121-2-12
Plyte SE, Hughes K, Nikolakaki E; et al. (1993). «Glycogen synthase kinase-3: functions in oncogenesis and development.». Biochim. Biophys. Acta. 1114 (2-3): 147–62. PMID 1333807
Morishima-Kawashima M, Hasegawa M, Takio K; et al. (1995). «Hyperphosphorylation of tau in PHF.». Neurobiol. Aging. 16 (3): 365–71; discussion 371–80. PMID 7566346. doi:10.1016/0197-4580(95)00027-C
Jope RS, Bijur GN (2002). «Mood stabilizers, glycogen synthase kinase-3beta and cell survival.». Mol. Psychiatry. 7 Suppl 1: S35–45. PMID 11986994. doi:10.1038/sj.mp.4001017
Bhat RV, Budd SL (2003). «GSK3beta signalling: casting a wide net in Alzheimer's disease.». Neurosignals. 11 (5): 251–61. PMID 12566926. doi:10.1159/000067423
Nadri C, Kozlovsky N, Agam G (2003). «[Schizophrenia, neurodevelopment and glycogen synthase kinase-3]». Harefuah. 142 (8-9): 636–42, 644. PMID 14518171
Mulholland DJ, Dedhar S, Wu H, Nelson CC (2006). «PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer.». Oncogene. 25 (3): 329–37. PMID 16421604. doi:10.1038/sj.onc.1209020