National Society of Film Critics Award for Best Supporting Actress (1999) (for verk: Boys Don't Cry) Independent Spirit Award for Best Supporting Female (2000) (for verk: Boys Don't Cry) Golden Globe Award for Best Supporting Actress – Series, Miniseries or Television Film (2010) (for verk: Big Love)
Chloë fikk sin debutrolle i filmen Kids da hun var 18 år. Da jobbet hun allerede som rådgiver for motemagasinet Sassy og var kjent for sin klesstil i New Yorks innerkreteser.