Anthony Charles Edwards (rollefigur: Mark Greene)
George Clooney (rollefigur: Doug Ross)
Sherry Stringfield (rollefigur: Susan Lewis)
Noah Wyle (rollefigur: John Carter)
Eriq La Salle (rollefigur: Peter Benton)
Linda Cardellini (rollefigur: Samantha Taggart)
Shane West (rollefigur: Ray Barnett)
Parminder Nagra (rollefigur: Neela Rasgotra)
Laura Innes (rollefigur: Kerry Weaver)
Maura Tierney (rollefigur: Abby Lockhart)
Erik Palladino (rollefigur: Dave Malucci)
Yvonne Zima