가바펜티노이드

α2δ(α2δ,알파2-델타) 리간드로도 알려진 가바펜티노이드(Gabapentinoid) 또는 가바펜티노이드계(Gabapentinoids)는 α2δ 서브유닛함유의 전압의존성 칼슘채널(VDCC)을 차단하는 억제성 신경전달물질 γ-아미노뷰티르산(GABA) 또는 GABA 유사체의 유도체인 약물 계열이다.[1][2][3][4] 이 부위는 약물 가바펜틴 및 프레가발린의 표적이기 때문에 가바펜틴 수용체(α2δ 서브유닛)로 지칭되었다.[5]

호흡기계통

미국 식품의약품청(FDA)은 가바펜티노이드계열의 성분이 신체 호흡기 계통에서 중추신경계억제제 병용투여와 같은 특정 위험요인과 교차했을 때 이상징후나 호흡곤란등의 발생위험을 확인했다고 발표한바있다.[6]

같이 보기

각주

  1. ↑ Calandre EP, Rico-Villademoros F, Slim M (2016). “Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use”. 《Expert Rev Neurother》 16 (11): 1263–1277. doi:10.1080/14737175.2016.1202764. PMID 27345098. 
  2. ↑ Dooley DJ, Taylor CP, Donevan S, Feltner D (2007). “Ca2+ channel alpha2delta ligands: novel modulators of neurotransmission”. 《Trends Pharmacol. Sci.》 28 (2): 75–82. doi:10.1016/j.tips.2006.12.006. PMID 17222465. 
  3. ↑ Elaine Wyllie; Gregory D. Cascino; Barry E. Gidal; Howard P. Goodkin (2012년 2월 17일). 《Wyllie's Treatment of Epilepsy: Principles and Practice》. Lippincott Williams & Wilkins. 423쪽. ISBN 978-1-4511-5348-4. 
  4. ↑ Honorio Benzon; James P. Rathmell; Christopher L. Wu; Dennis C. Turk; Charles E. Argoff; Robert W Hurley (2013년 9월 11일). 《Practical Management of Pain》. Elsevier Health Sciences. 1006쪽. ISBN 978-0-323-17080-2. 
  5. ↑ Eroglu, Çagla; Allen, Nicola J.; Susman, Michael W.; O'Rourke, Nancy A.; Park, Chan Young; Özkan, Engin; Chakraborty, Chandrani; Mulinyawe, Sara B.; Annis, Douglas S.; Huberman, Andrew D.; Green, Eric M.; Lawler, Jack; Dolmetsch, Ricardo; Garcia, K. Christopher; Smith, Stephen J.; Luo, Z. David; Rosenthal, Arnon; Mosher, Deane F.; Barres, Ben A. (2009). “Gabapentin Receptor α2δ-1 is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis”. 《Cell》 139 (2): 380–92. doi:10.1016/j.cell.2009.09.025. PMC 2791798. PMID 19818485. 
  6. ↑ (식품의약품안전처-의약품 안전성 서한 배포 알림(가바펜티노이드계 성분제제)의약품통합정보시스템)https://nedrug.mfds.go.kr/pbp/CCBAC01/getItem?safeLetterNo=436

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