サイクリンC

CCNC
PDBに登録されている構造 PDB オルソログ検索: RCSB PDBe PDBj PDBのIDコード一覧 3RGF, 4F6S, 4F6U, 4F6W, 4F70, 4F7J, 4F7L, 4F7N, 4F7S, 4G6L, 4CRL, 5HBE, 5HBH, 5BNJ, 5HBJ, 5FGK, 5CEI, 5HNB, 5HVY, 5I5Z
識別子
記号	CCNC, CycC, cyclin C, hSRB11, SRB11
外部ID	OMIM: 123838 MGI: 1858199 HomoloGene: 3803 GeneCards: CCNC
遺伝子の位置 (ヒト) 染色体 6番染色体 (ヒト)[1] バンド データ無し 開始点 99,542,387 bp[1] 終点 99,568,825 bp[1]
遺伝子の位置 (マウス) 染色体 4番染色体 (マウス)[2] バンド データ無し 開始点 21,727,701 bp[2] 終点 21,759,922 bp[2]
RNA発現パターン さらなる参照発現データ
遺伝子オントロジー 分子機能 • 血漿タンパク結合 • protein serine/threonine kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity 細胞の構成要素 • メディエーター • cyclin-dependent protein kinase holoenzyme complex • 細胞核 • 核質 生物学的プロセス • positive regulation of phosphorylation of RNA polymerase II C-terminal domain • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • positive regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of transcription by RNA polymerase II • タンパク質リン酸化 • transcription, DNA-templated • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of transcription by RNA polymerase II • regulation of protein kinase activity 出典:Amigo / QuickGO
オルソログ
種	ヒト	マウス
Entrez	892	51813
Ensembl	ENSG00000112237	ENSMUSG00000028252
UniProt	P24863,H0YBQ5	Q62447
RefSeq (mRNA)	NM_001013399 NM_005190 NM_001363537	NM_001122982 NM_001290420 NM_001290422 NM_016746
RefSeq (タンパク質)	NP_001013417 NP_005181 NP_001350466	NP_001116454 NP_001277349 NP_001277351 NP_058026
場所 (UCSC)	Chr 6: 99.54 – 99.57 Mb	Chr 6: 21.73 – 21.76 Mb
PubMed検索	[3]	[4]
ウィキデータ
閲覧/編集 ヒト 閲覧/編集 マウス

サイクリンC（英: cyclin C）は、ヒトではCCNC遺伝子にコードされるタンパク質である^[5][6]。

CCNC遺伝子にコードされるサイクリンCは、サイクリンファミリーに属するタンパク質である。サイクリンCはサイクリン依存性キナーゼ8（英語版）と相互作用し、RNAポリメラーゼIIの大サブユニットのC末端ドメインのリン酸化を誘導する。この遺伝子のmRNAレベルは細胞周期のG₁期にピークに達する。この遺伝子には異なるアイソフォームをコードする2つの転写バリアントが見つかっている^[6]。

相互作用

サイクリンCはエストロゲン受容体α^[7]、サイクリン依存性キナーゼ8（英語版）と相互作用することが示されている^{[7][8][9][10][11]}。

出典

1. ^ GRCh38: Ensembl release 89: ENSG00000112237 - Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028252 - Ensembl, May 2017
3. Human PubMed Reference:
4. Mouse PubMed Reference:
5. “Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast”. Cell 66 (6): 1197–206. (Oct 1991). doi:10.1016/0092-8674(91)90042-W. PMID 1833066. 
6. ^ “Entrez Gene: CCNC cyclin C”. 2021年11月22日閲覧。
7. ^ Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). “The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro”. Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Bibcode: 2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122401/. 
8. Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). “Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex”. Cell 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. ISSN 0092-8674. PMID 9150135. 
9. Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). “A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure”. Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. ISSN 0270-7306. PMC 109120. PMID 9710619. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109120/. 
10. Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). “Characterization of Mediator Complexes from HeLa Cell Nuclear Extract”. Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC87123/. 
11. Tassan, J P; Jaquenoud M; Léopold P; Schultz S J; Nigg E A (Sep 1995). “Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C”. Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode: 1995PNAS...92.8871T. doi:10.1073/pnas.92.19.8871. ISSN 0027-8424. PMC 41069. PMID 7568034. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41069/. 

関連文献

• “Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II)”. Bioinorganic Chemistry 5 (3): 267–73. (1976). doi:10.1016/S0006-3061(00)82025-6. PMID 1260071. 
• “Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C”. Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. (1995). Bibcode: 1995PNAS...92.8871T. doi:10.1073/pnas.92.19.8871. PMC 41069. PMID 7568034. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41069/. 
• “Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)”. Cytogenet. Cell Genet. 69 (3–4): 190–2. (1995). doi:10.1159/000133960. PMID 7698009. 
• “Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts”. J. Clin. Invest. 95 (5): 2275–80. (1995). doi:10.1172/JCI117918. PMC 295840. PMID 7738192. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC295840/. 
• “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene 138 (1–2): 171–4. (1994). doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• “Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II”. Oncogene 12 (12): 2631–40. (1996). PMID 8700522. 
• “Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors”. Genomics 32 (2): 253–9. (1997). doi:10.1006/geno.1996.0112. PMID 8833152. 
• “The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme”. Mol. Cell. Biol. 17 (4): 1817–23. (1997). doi:10.1128/MCB.17.4.1817. PMC 232028. PMID 9121429. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232028/. 
• “Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. (1997). doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• “Factors associated with the mammalian RNA polymerase II holoenzyme”. Nucleic Acids Res. 26 (3): 847–53. (1998). doi:10.1093/nar/26.3.847. PMC 147327. PMID 9443979. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147327/. 
• “A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure”. Mol. Cell. Biol. 18 (9): 5355–63. (1998). doi:10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109120/. 
• “NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription”. Mol. Cell 2 (2): 213–22. (1998). doi:10.1016/S1097-2765(00)80131-8. PMID 9734358. 
• “A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation”. Mol. Cell 3 (1): 97–108. (1999). doi:10.1016/S1097-2765(00)80178-1. PMID 10024883. 
• “Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators”. Mol. Cell 3 (3): 361–70. (1999). doi:10.1016/S1097-2765(00)80463-3. PMID 10198638. 
• “Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex”. Nature 398 (6730): 824–8. (1999). Bibcode: 1999Natur.398..824R. doi:10.1038/19783. PMID 10235266. 
• “Characterization of Mediator Complexes from HeLa Cell Nuclear Extract”. Mol. Cell. Biol. 21 (14): 4604–13. (2001). doi:10.1128/MCB.21.14.4604-4613.2001. PMC 87123. PMID 11416138. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC87123/. 
• “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). Bibcode: 2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• “Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3”. J. Biol. Chem. 278 (17): 15123–7. (2003). doi:10.1074/jbc.C300054200. PMID 12584197. 
• “Cyclin C expression is involved in the pathogenesis of Alzheimer's disease”. Neurobiol. Aging 24 (3): 427–35. (2003). doi:10.1016/S0197-4580(02)00132-X. PMID 12600719. 

外部リンク

• Human CCNC genome location and CCNC gene details page in the UCSC Genome Browser.