Recettore per la beta-linfotossina

Recettore per la beta-linfotossina
Struttura del recettore della beta-linfotossina legato a TRAF3
Gene
HUGO	LTBR D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3
Entrez	4055
Locus	Chr. 12 p13.31
Proteina
OMIM	600979
UniProt	P36941

Il recettore per la beta-linfotossina, anche noto come recettore del fattore di necrosi tumorale 3, è una proteina recettoriale che, nell'essere umano, è codificata dal gene LTBR e fa parte della superfamiglia dei recettori del fattore di necrosi tumorale^[1][2][3].

Funzione

Tale recettore si trova espresso sulla maggior parte dei tipi cellulari, tra cui quelli epiteliali e quelli delle linee mieloidi prodotte dal midollo emopoietico, ma non sui linfociti T e B. Lega specificatamente la linfotossina, un complesso formato da due proteine, la linfotossina-α e la linfotossina-β, una volta conosciuto come TNF-β. È coinvolto nello sviluppo e nell'organizzazione del tessuto linfoide secondario e la sua attivazione può indurre il processo di morte cellulare programmata^[1], interagendo con SMAC^[4] e TRAF3^[5][6][7].

Oltre a indurre l'apoptosi, porta al rilascio di interleuchina 8, soprattutto a livello delle cellule HEK^[8].

Note

1. Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3), su ncbi.nlm.nih.gov.
2. Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P, Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid, in Genomics, vol. 16, n. 1, aprile 1993, pp. 214–8, DOI:10.1006/geno.1993.1161, PMID 8486360.
3. Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA, A lymphotoxin-beta-specific receptor, in Science, vol. 264, n. 5159, aprile 1994, pp. 707–10, DOI:10.1126/science.8171323, PMID 8171323.
4. Jun Kuai, Nickbarg Elliott, Wooters Joe, Qiu Yongchang, Wang Jack, Lin Lih-Ling, Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis, in J. Biol. Chem., vol. 278, n. 16, United States, aprile 2003, pp. 14363–9, DOI:10.1074/jbc.M208672200, ISSN 0021-9258 (WC · ACNP), PMID 12571250.
5. T L VanArsdale, VanArsdale S L, Force W R, Walter B N, Mosialos G, Kieff E, Reed J C, Ware C F, Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB, in Proc. Natl. Acad. Sci. U.S.A., vol. 94, n. 6, UNITED STATES, marzo 1997, pp. 2460–5, DOI:10.1073/pnas.94.6.2460, ISSN 0027-8424 (WC · ACNP), PMC 20110, PMID 9122217.
6. M Y Wu, Wang P Y, Han S H, Hsieh S L, The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells, in J. Biol. Chem., vol. 274, n. 17, UNITED STATES, aprile 1999, pp. 11868–73, DOI:10.1074/jbc.274.17.11868, ISSN 0021-9258 (WC · ACNP), PMID 10207006.
7. S A Marsters, Ayres T M, Skubatch M, Gray C L, Rothe M, Ashkenazi A, Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1, in J. Biol. Chem., vol. 272, n. 22, UNITED STATES, maggio. 1997, pp. 14029–32, DOI:10.1074/jbc.272.22.14029, ISSN 0021-9258 (WC · ACNP), PMID 9162022.
8. Chang YH, Hsieh SL, Chen MC, Lin WW, Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation, in Exp. Cell Res., vol. 278, n. 2, agosto 2002, pp. 166–74, DOI:10.1006/excr.2002.5573, PMID 12169272.

Bibliografia

• Elewaut D, Ware CF, The unconventional role of LT alpha beta in T cell differentiation., in Trends Immunol., vol. 28, n. 4, 2007, pp. 169–75, DOI:10.1016/j.it.2007.02.005, PMID 17336158.
• Browning JL, Ngam-ek A, Lawton P, et al., Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface., in Cell, vol. 72, n. 6, 1993, pp. 847–56, DOI:10.1016/0092-8674(93)90574-A, PMID 7916655.
• Crowe PD, VanArsdale TL, Walter BN, et al., A lymphotoxin-beta-specific receptor., in Science, vol. 264, n. 5159, 1994, pp. 707–10, DOI:10.1126/science.8171323, PMID 8171323.
• Baens M, Chaffanet M, Cassiman JJ, et al., Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid., in Genomics, vol. 16, n. 1, 1993, pp. 214–8, DOI:10.1006/geno.1993.1161, PMID 8486360.
• Baens M, Aerssens J, van Zand K, et al., Isolation and regional assignment of human chromosome 12p cDNAs., in Genomics, vol. 29, n. 1, 1996, pp. 44–52, DOI:10.1006/geno.1995.1213, PMID 8530100.
• Wang X, Bornslaeger EA, Haub O, et al., A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein., in Dev. Biol., vol. 177, n. 1, 1996, pp. 274–90, DOI:10.1006/dbio.1996.0162, PMID 8660894.
• Nakano H, Oshima H, Chung W, et al., TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor., in J. Biol. Chem., vol. 271, n. 25, 1996, pp. 14661–4, DOI:10.1074/jbc.271.25.14661, PMID 8663299.
• Matsumoto M, Hsieh TY, Zhu N, et al., Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor., in J. Virol., vol. 71, n. 2, 1997, pp. 1301–9, PMC 191185, PMID 8995654.
• VanArsdale TL, VanArsdale SL, Force WR, et al., Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB., in Proc. Natl. Acad. Sci. U.S.A., vol. 94, n. 6, 1997, pp. 2460–5, DOI:10.1073/pnas.94.6.2460, PMC 20110, PMID 9122217.
• Wu MY, Hsu TL, Lin WW, et al., Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells., in J. Biol. Chem., vol. 272, n. 27, 1997, pp. 17154–9, DOI:10.1074/jbc.272.27.17154, PMID 9202035.
• Chen CM, You LR, Hwang LH, Lee YH, Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor., in J. Virol., vol. 71, n. 12, 1997, pp. 9417–26, PMC 230246, PMID 9371602.
• Mizushima S, Fujita M, Ishida T, et al., Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)., in Gene, vol. 207, n. 2, 1998, pp. 135–40, DOI:10.1016/S0378-1119(97)00616-1, PMID 9511754.
• Krajewska M, Krajewski S, Zapata JM, et al., TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues., in Am. J. Pathol., vol. 152, n. 6, 1998, pp. 1549–61, PMC 1858434, PMID 9626059.
• Boussaud V, Soler P, Moreau J, et al., Expression of three members of the TNF-R family of receptors (4-1BB, lymphotoxin-beta receptor, and Fas) in human lung., in Eur. Respir. J., vol. 12, n. 4, 1999, pp. 926–31, DOI:10.1183/09031936.98.12040926, PMID 9817170.
• Murphy M, Walter BN, Pike-Nobile L, et al., Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues., in Cell Death Differ., vol. 5, n. 6, 1999, pp. 497–505, DOI:10.1038/sj.cdd.4400374, PMID 10200501.
• Wu MY, Wang PY, Han SH, Hsieh SL, The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells., in J. Biol. Chem., vol. 274, n. 17, 1999, pp. 11868–73, DOI:10.1074/jbc.274.17.11868, PMID 10207006.
• Yu KY, Kwon B, Ni J, et al., A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis., in J. Biol. Chem., vol. 274, n. 20, 1999, pp. 13733–6, DOI:10.1074/jbc.274.20.13733, PMID 10318773.
• Rooney IA, Butrovich KD, Glass AA, et al., The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells., in J. Biol. Chem., vol. 275, n. 19, 2000, pp. 14307–15, DOI:10.1074/jbc.275.19.14307, PMID 10799510.
• Langeggen H, Berge KE, Johnson E, Hetland G, Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro., in Inflammation, vol. 26, n. 3, 2003, pp. 103–10, DOI:10.1023/A:1015585530204, PMID 12083416.
• Chang YH, Hsieh SL, Chen MC, Lin WW, Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation., in Exp. Cell Res., vol. 278, n. 2, 2002, pp. 166–74, DOI:10.1006/excr.2002.5573, PMID 12169272.

Voci correlate

• Recettore del fattore di necrosi tumorale